Journal article
The-1541 C > T and+4259 G > T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population
International journal of immunogenetics, Vol.38(6), pp.513-518
12/01/2011
DOI: 10.1111/j.1744-313X.2011.01046.x
PMID: 21989170
Abstract
The T-cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to be associated with susceptibility to rheumatoid arthritis (RA). In this study, we investigated the association of four single-nucleotide polymorphisms (SNPs) of the TIM-3 gene with RA susceptibility in Chinese Hui and Han groups. Using restriction fragment length or sequence-specific primerpolymerase chain reaction (PCR), patients with RA and nonarthritis control individuals from these two ethnicities were analysed for SNPs of -1541 C>T, -882 T>C, -574 T>G and +4259 G>T, in the TIM-3 gene. Our results demonstrated that the polymorphisms of +4259 G>T SNP of TIM-3 gene was associated with the RA susceptibility in both the Hui (P < 0.01) and Han populations (P < 0.05). However, the -1541 C>T and -574 T>G SNPs were distinctly associated with RA for the Hui and Han populations, respectively. In addition, haplotype analysis found no statistically differences in the distribution of nine detected haplotype frequency between patients with RA and controls in this study (P > 0.05). These findings suggest that polymorphism of +4259 G>T in TIM-3 gene may be one of the most important genetic factors associated with the RA susceptibility among different populations, and genetic variations of TIM-3 gene contribute to RA susceptibility among different populations.
Details
- Title: Subtitle
- The-1541 C > T and+4259 G > T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population
- Creators
- J. Xu - Ningxia UniversityY. Yang - Ningxia UniversityX. Liu - Ningxia UniversityY. Wang - Ningxia University
- Resource Type
- Journal article
- Publication Details
- International journal of immunogenetics, Vol.38(6), pp.513-518
- Publisher
- Wiley
- DOI
- 10.1111/j.1744-313X.2011.01046.x
- PMID
- 21989170
- ISSN
- 1744-3121
- eISSN
- 1744-313X
- Number of pages
- 6
- Grant note
- NZ0933 / Natural Science Foundation of Ningxia Hui Autonomous Region of China Grant of Project on Scientific Research for Colleges and Universities in Ningxia Grant of Science and Technology Program of Ningxia
- Language
- English
- Date published
- 12/01/2011
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984284333902771
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