The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Mark M Pomerantz; Nasim Ahmadiyeh; Li Jia; Paula Herman; Michael P Verzi; Harshavardhan Doddapaneni; Christine A Beckwith; Jennifer A Chan; Adam Hills; Matt Davis; Keluo Yao; Sarah M Kehoe; Heinz-Josef Lenz; Christopher A Haiman; Chunli Yan; Brian E Henderson; Baruch Frenkel; Jordi Barretina; Adam Bass; Josep Tabernero; José Baselga; Meredith M Regan; J Robert Manak; Ramesh Shivdasani; Gerhard A Coetzee; Matthew L Freedman

doi:10.1038/ng.403

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Journal article

Peer reviewed

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Mark M Pomerantz, Nasim Ahmadiyeh, Li Jia, Paula Herman, Michael P Verzi, Harshavardhan Doddapaneni, Christine A Beckwith, Jennifer A Chan, Adam Hills, Matt Davis, …

Nature genetics, Vol.41(8), pp.882-884

08/2009

DOI: 10.1038/ng.403

PMCID: PMC2763485

PMID: 19561607

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https://www.ncbi.nlm.nih.gov/pmc/articles/2763485View

Open Access

Abstract

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.

TCF Transcription Factors - metabolism

Chromosomes, Human, Pair 8 - genetics

Genetic Predisposition to Disease

Colorectal Neoplasms - genetics

Humans

Alleles

Cell Line, Tumor

Polymorphism, Single Nucleotide - genetics

Protein Binding

Enhancer Elements, Genetic - genetics

Proto-Oncogene Proteins c-myc - genetics

Transcription Factor 7-Like 2 Protein

Details

Title: Subtitle: The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Creators: Mark M Pomerantz - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Nasim Ahmadiyeh
Li Jia
Paula Herman
Michael P Verzi
Harshavardhan Doddapaneni
Christine A Beckwith
Jennifer A Chan
Adam Hills
Matt Davis
Keluo Yao
Sarah M Kehoe
Heinz-Josef Lenz
Christopher A Haiman
Chunli Yan
Brian E Henderson
Baruch Frenkel
Jordi Barretina
Adam Bass
Josep Tabernero
José Baselga
Meredith M Regan
J Robert Manak
Ramesh Shivdasani
Gerhard A Coetzee
Matthew L Freedman
Resource Type: Journal article
Publication Details: Nature genetics, Vol.41(8), pp.882-884
DOI: 10.1038/ng.403
PMID: 19561607
PMCID: PMC2763485
NLM abbreviation: Nat Genet
ISSN: 1061-4036
eISSN: 1546-1718
Publisher: United States
Grant note: K08 CA134931 / NCI NIH HHS R01 CA129435 / NCI NIH HHS 5P50CA90381 / NCI NIH HHS R01 CA109147 / NCI NIH HHS Howard Hughes Medical Institute R01 CA136924 / NCI NIH HHS P50 CA090381 / NCI NIH HHS R01 CA109147-04 / NCI NIH HHS
Language: English
Date published: 08/2009
Academic Unit: Stead Family Department of Pediatrics; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9983991961702771

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