Journal article
The ABCF gene family facilitates disaggregation during animal development
Molecular biology of the cell, Vol.31(13), pp.1324-1345
A Highlights from
06/15/2020
DOI: 10.1091/mbc.E19-08-0443
PMCID: PMC7353142
PMID: 32320318
Abstract
Protein aggregation, once believed to be a harbinger and/or consequence of stress, age, and pathological conditions, is emerging as a novel concept in cellular regulation. Normal versus pathological aggregation may be distinguished by the capacity of cells to regulate the formation, modification, and dissolution of aggregates. We find that
Caenorhabditis elegans
aggregates are observed in large cells/blastomeres (oocytes, embryos) and in smaller, further differentiated cells (primordial germ cells), and their analysis using cell biological and genetic tools is straightforward. These observations are consistent with the hypothesis that aggregates are involved in normal development. Using cross-platform analysis in
Saccharomyces cerevisiae, C. elegans
, and
Xenopus laevis
, we present studies identifying a novel disaggregase family encoded by animal genomes and expressed embryonically. Our initial analysis of yeast Arb1/Abcf2 in disaggregation and animal ABCF proteins in embryogenesis is consistent with the possibility that members of the ABCF gene family may encode disaggregases needed for aggregate processing during the earliest stages of animal development.
Details
- Title: Subtitle
- The ABCF gene family facilitates disaggregation during animal development
- Creators
- Sydney Skuodas - Department of Biology, University of Iowa, Iowa City, IA 52242Amy Clemons - Department of Biology, University of Iowa, Iowa City, IA 52242Michael Hayes - Department of Biochemistry, University of Iowa, Iowa City, IA 52242Ashley Goll - Department of Biochemistry, University of Iowa, Iowa City, IA 52242Betul Zora - Department of Biology, University of Iowa, Iowa City, IA 52242Daniel L Weeks - Department of Biochemistry, University of Iowa, Iowa City, IA 52242Bryan T Phillips - Department of Biology, University of Iowa, Iowa City, IA 52242Jan S Fassler - Department of Biology, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Molecular biology of the cell, Vol.31(13), pp.1324-1345
- Publisher
- The American Society for Cell Biology
- Series
- A Highlights from
- DOI
- 10.1091/mbc.E19-08-0443
- PMID
- 32320318
- PMCID
- PMC7353142
- ISSN
- 1059-1524
- eISSN
- 1939-4586
- Language
- English
- Date published
- 06/15/2020
- Academic Unit
- Stead Family Department of Pediatrics; Biology; Biochemistry and Molecular Biology
- Record Identifier
- 9984217426102771
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