Journal article
The ARDS, Pneumonia, and Sepsis (APS) Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes
Chest
07/13/2026
DOI: 10.1016/j.chest.2026.05.053
PMID: 42442528
Abstract
To enhance biological understanding of acute respiratory distress syndrome (ARDS), pneumonia, and sepsis and accelerate therapeutic development in these areas, the National Institutes of Health developed the ARDS, Pneumonia, and Sepsis (APS) Consortium.
Is the APS Consortium study rapidly generating data and biospecimens from a large cohort of critically ill adults with ARDS, pneumonia, and sepsis that will facilitate phenotyping of these syndromes?
The APS Consortium Phenotyping Study is a multicenter longitudinal prospective observational cohort study aimed at enrolling 4,000 critically ill adults with ARDS, pneumonia, and/or sepsis over 4 years. Data and biospecimens are collected to characterize many aspects of each participant's chronic health, acute illness, and long-term recovery to facilitate phenotyping-that is, subclassifying ARDS, pneumonia, and sepsis into precise biologically-based subsets with shared pathophysiology. Feasibility of the study was assessed by evaluating the first 1,000 participants in terms of recruitment pace, participant characteristics, biospecimen collection, and proportion with confirmed ARDS, pneumonia, and sepsis based on expert adjudication.
The first 1,000 participants were recruited ahead of schedule in less than 13 months. Median age was 64 years, 75% received vasopressors, 50% received invasive mechanical ventilation, and 25% died in the hospital within 4 weeks of enrollment. Biospecimen collection rates were high, with 99% of participants with blood, 98% with upper respiratory swabs, 37% with lower respiratory samples, 80% with urine, and 65% with gastrointestinal samples. Expert adjudication resulted in 40% classified with ARDS, 52% with pneumonia, and 89% with sepsis.
The APS Consortium Phenotyping Study is producing a cohort of critically ill adults with ARDS, pneumonia, and sepsis with high severity of disease and a rich set of data and biospecimens. The study will continue to full enrollment of 4,000 participants.
Clinicaltrials.gov NCT06521502.
Details
- Title: Subtitle
- The ARDS, Pneumonia, and Sepsis (APS) Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes
- Creators
- Wesley H Self - Vanderbilt University Medical CenterCarolyn S Calfee - University of California, San FranciscoSamuel M Brown - Intermountain Medical CenterMarc Moss - University of Colorado DenverLorraine B Ware - Vanderbilt UniversityRobert C Hyzy - University of MichiganNuala J Meyer - University of PennsylvaniaJohn P Reilly - University of PennsylvaniaMichael O Harhay - University of PennsylvaniaMichael G S Shashaty - University of PennsylvaniaDanielle K Sandsmark - University of PennsylvaniaCatherine L Auriemma - University of PennsylvaniaTiffanie K Jones - University of PennsylvaniaHallie C Prescott - University of MichiganRobert P Dickson - University of MichiganKristine Nelson - University of MichiganJakob I McSparron - University of MichiganMadeline Lagina - University of MichiganScott J Denstaedt - University of MichiganAndrew J Admon - VA Center for Clinical Management ResearchBhakti K Patel - University of ChicagoKrysta S Wolfe - University of Illinois ChicagoR Duncan Hite - University of Cincinnati Medical CenterKristin M Hudock - University of CincinnatiJulie A Bastarache - Vanderbilt University Medical CenterTatsuki Koyama - Vanderbilt University Medical CenterV Eric Kerchberger - Vanderbilt University Medical CenterE Wesley Ely - Geriatric Research Education and Clinical CenterJames C Jackson - Vanderbilt University Medical CenterPratik Sinha - Washington University in St. LouisPhilip A Mudd - Washington University in St. LouisBryan D Kraft - Washington University in St. LouisRichard D Fremont - Meharry Medical CollegeRajbir Singh - Meharry Medical CollegeNeil R Aggarwal - University of Colorado Anschutz Medical CampusSarah E Jolley - University of Colorado Anschutz Medical CampusEllen L Burnham - University of Colorado DenverRafaela A Mantelli - University of Colorado Anschutz Medical CampusWilliam J Janssen - National Jewish HealthCamille M Moore - National Jewish HealthIvor S Douglas - Westchester Medical CenterRyan Peterson - University of IowaIthan D Peltan - Intermountain Medical CenterChristina E Barkauskas - Duke UniversityElias H Pratt - Duke UniversityEstelle S Harris - University of UtahDaniel O Scharfstein - University of UtahDale M Needham - Johns Hopkins UniversitySarina K Sahetya - Johns Hopkins UniversityAnn M Parker - Johns Hopkins UniversityTheodore J Iwashyna - Johns Hopkins UniversityKevin Shenderov - Johns Hopkins UniversityMichael A Matthay - University of California, San FranciscoNarges Alipanah-Lechner - University of California, San FranciscoLiam Magee - University of California, San FranciscoTal Shwartzman - University of California, San FranciscoChelsea Lin - University of California, San FranciscoMelanie F Weingart - University of California, San FranciscoCharles R Langelier - University of California, San FranciscoOlivia Chao - University of California, San FranciscoCarolyn M Hendrickson - San Francisco General HospitalLucy Z Kornblith - San Francisco General HospitalSuzanna Chak - San Francisco General HospitalKim Bardillon - San Francisco General HospitalKimberly Herrera Rodriguez - University of California, San FranciscoAngela J Rogers - Stanford UniversityAndrew R Moore - Stanford UniversityJoseph E Levitt - Palo Alto UniversityRosemary Vojnik - Stanford UniversityCynthia Perez - Stanford UniversityChristopher J Lindsell - Duke UniversityMatthew S Shotwell - Vanderbilt University Medical CenterBryan S Blette - Vanderbilt University Medical CenterBrant W Imhoff - Vanderbilt University Medical CenterTodd W Rice - Vanderbilt University Medical CenterJillian P Rhoads - Vanderbilt University Medical CenterKelsey N Womack - Vanderbilt University Medical CenterAlyssa R Merkel - Vanderbilt University Medical CenterLillian N Ahmad - Vanderbilt University Medical CenterXiaoli Zhao - National Institutes of HealthIngrid Espinoza Grandon - National Heart Lung and Blood InstituteMichelle Ng Gong - Albert Einstein College of MedicineARDS, Pneumonia, and Sepsis (APS) Consortium
- Resource Type
- Journal article
- Publication Details
- Chest
- DOI
- 10.1016/j.chest.2026.05.053
- PMID
- 42442528
- NLM abbreviation
- Chest
- ISSN
- 1931-3543
- eISSN
- 1931-3543
- Publisher
- Elsevier
- Language
- English
- Electronic publication date
- 07/13/2026
- Academic Unit
- Biostatistics; Internal Medicine
- Record Identifier
- 9985182471202771
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