Journal article
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
Neuron (Cambridge, Mass.), Vol.34(3), pp.463-477
2002
DOI: 10.1016/S0896-6273(02)00661-X
PMID: 11988176
Abstract
Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H
+-gated currents in hippocampal neurons. Neuronal H
+-gated currents and transient acidification are proposed to play a role in synaptic transmission. Investigating this possibility, we found ASIC in hippocampus, in synaptosomes, and in dendrites localized at synapses. Moreover, loss of ASIC impaired hippocampal long-term potentiation. ASIC null mice had reduced excitatory postsynaptic potentials and NMDA receptor activation during high-frequency stimulation. Consistent with these findings, null mice displayed defective spatial learning and eyeblink conditioning. These results identify ASIC as a key component of acid-activated currents and implicate these currents in processes underlying synaptic plasticity, learning, and memory.
Details
- Title: Subtitle
- The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
- Creators
- John A Wemmie - Department of Psychiatry, University of Iowa, Iowa City, IA 52242 USAJianguo Chen - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USACandice C Askwith - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 USAAlesia M Hruska-Hageman - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 USAMargaret P Price - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 USABrian C Nolan - Department of Psychology, University of Iowa, Iowa City, IA 52242 USAPatrick G Yoder - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 USAEjvis Lamani - Department of Psychiatry, University of Iowa, Iowa City, IA 52242 USAToshinori Hoshi - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USAJohn H Freeman - Department of Psychology, University of Iowa, Iowa City, IA 52242 USAMichael J Welsh - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.34(3), pp.463-477
- DOI
- 10.1016/S0896-6273(02)00661-X
- PMID
- 11988176
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984003429302771
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