Journal article
The Artificial Urinary Sphincter Improves Emotional Health in Men with Stress Urinary Incontinence: Results from the Prospective, Multi-institutional AUSCO Study
Urology (Ridgewood, N.J.), Vol.207, pp.227-232
01/2026
DOI: 10.1016/j.urology.2025.09.037
PMID: 41043618
Abstract
To examine the effects on depression, anxiety and overall emotional health in patients undergoing artificial urinary sphincter (AUS) surgery for stress urinary incontinence (SUI). Few reports focus on the impact of AUS implantation on emotional health in men with SUI.
The Artificial Urinary Sphincter Clinical Outcomes Trial (AUSCO) was a prospective, single-arm, multi-site study designed to evaluate outcomes in men with SUI treated with the AMS 800™ AUS (NCT04088331). A total of 115 subjects were implanted. Follow-up assessments at 3-, 6-, and 12-months post device activation were compared to baseline. These analyses focus on emotional health, measured with the Incontinence QOL (I-QOL), Incontinence Impact Questionnaire (IIQ-7), and EQ-5D-5L.
At 12 months, 100 had completed QOL assessments. Depression rating (Item 5, I-QOL) significantly improved, with 85% (85/100) of patients reporting feeling at least "a little" depressed at baseline decreasing to 39% (39/100) at 12 months (p<0.0001). Emotional health rating (Item 6, IIQ-7) also improved, with 16% (16/100) reporting being "greatly" affected by incontinence at baseline decreasing to 3% (3/100) at 12 months (p<0.0001). The anxiety/depression domain on the EQ-5D-5L (Item 5) was also significantly improved, with 50% (50/100) of patients reporting being at least "slightly" anxious or depressed at baseline decreasing to 30% (30/100) at 12 months (p = <0.0001).
These data demonstrate that treatment of SUI with the AUS improves emotional health in men with SUI.
Details
- Title: Subtitle
- The Artificial Urinary Sphincter Improves Emotional Health in Men with Stress Urinary Incontinence: Results from the Prospective, Multi-institutional AUSCO Study
- Creators
- Andrew C Peterson - Duke Medical CenterHadley M Wood - Glickman Urological Institute, Cleveland, OH. Electronic address: woodh@ccf.orgJeremy Myers - University of UtahBenjamin N Breyer - University of California, San FranciscoBradley A Erickson - University of Iowa Hospitals and ClinicsThomas G Smith III - The University of Texas MD Anderson Cancer CenterErin L Chaussee - Boston Scientific (United States)Melissa R Kaufman - Vanderbilt University Medical CenterRyan Terlecki - Atrium Health Wake Forest BaptistNiels V Johnsen - Vanderbilt University Medical CenterAlex J Vanni - Lahey Medical CenterDaniel Moon - The Royal Melbourne HospitalLeRoy Jones - Urology San AntonioJoshua A Broghammer - University of Kansas Medical CenterGerard Henry - Willis-Knighton Bossier Medical Center, Bossier City, LA. Electronic address: gdhenry@hotmail.comArthur L Burnett - Johns Hopkins UniversityLewis Wen Loong Chan - Concord Repatriation General HospitalBrian J Flynn - University of Colorado Anschutz Medical CampusRose Khavari - Cornell UniversitySean Elliott - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Urology (Ridgewood, N.J.), Vol.207, pp.227-232
- DOI
- 10.1016/j.urology.2025.09.037
- PMID
- 41043618
- NLM abbreviation
- Urology
- ISSN
- 1527-9995
- eISSN
- 1527-9995
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Grant note
Health Wake Forest Baptist, Niels V. Jonsen MD MPH at Vanderbilt University Medical Center, Alex J. Vanni MD at Lahey Hospital and Medical Center, Daniel Moon FRACS at University of Melbourne Royal Melbourne Clinical School, LeRoy Jones MD at Urology San Antonion Research, Joshua A. Broghammer MD at University of Kansas Medical Center, Gerard Henry MD at Willis-Knighton Bossier Medical Center, Arthur L. Burnett MD MBA at Johns Hopkins Medicine Institutions, Lewis Wen Loong Chan MBBS at Concord Repatriation General Hospital, Brian J. Flynn MD at University of Colorado Anschutz Medical Campus, Rose Khavari MD at Houston Methodist Hospital and Weill Cornell Medicine, and Sean Elliott MD MS at University of Minnesota. The authors thank Boston Scientific's Kaitlyn Rainbow for trial management, Webb Kang for statistical programming, and Laura Chapin for manuscript preparation.
- Language
- English
- Electronic publication date
- 10/01/2025
- Date published
- 01/2026
- Academic Unit
- Urology
- Record Identifier
- 9984969241502771
Metrics
6 Record Views