Journal article
The Assay of Clozapine and N-Desmethylclozapine in Human Plasma by High-Performance Liquid Chromatography
Therapeutic drug monitoring, Vol.13(1), pp.69-72
01/1991
DOI: 10.1097/00007691-199101000-00010
PMID: 2057995
Abstract
A high performance liquid chromatographic method for the simultaneous quantitation of clozapine--a member of the dibenzodiazepine class of antipsychotic drugs--and its reduced metabolite in human plasma has been developed. Clozapine and N-desmethylclozapine are concentrated from blood samples by liquid-liquid extraction, followed by reverse-phase liquid chromatography. Accuracy of the determination is ensured by application of an internal standard, protriptyline, which is closely related to clozapine. A detection limit of 15 ng/mL for clozapine and 30 ng/ml for N-desmethylclozapine was achieved.
Details
- Title: Subtitle
- The Assay of Clozapine and N-Desmethylclozapine in Human Plasma by High-Performance Liquid Chromatography
- Creators
- Michael J LovdahlPaul J PerryDel D Miller
- Resource Type
- Journal article
- Publication Details
- Therapeutic drug monitoring, Vol.13(1), pp.69-72
- DOI
- 10.1097/00007691-199101000-00010
- PMID
- 2057995
- ISSN
- 0163-4356
- eISSN
- 1536-3694
- Language
- English
- Date published
- 01/1991
- Academic Unit
- Pharmacy; Psychiatry
- Record Identifier
- 9984003904202771
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