The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience

Erik S. Davis; Peyton Seda; David Turaczyk Kolodziej; Aneli T. Villa; Lawrence Feng; Olivia DiGioia; Apoorve Nayyar; Faisal S. Jehan; Hassan Aziz

doi:10.1016/j.jss.2024.04.027

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The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience

Journal article

Peer reviewed

The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience

Erik S. Davis, Peyton Seda, David Turaczyk Kolodziej, Aneli T. Villa, Lawrence Feng, Olivia DiGioia, Apoorve Nayyar, Faisal S. Jehan and Hassan Aziz

The Journal of surgical research, Vol.299, pp.145-150

07/01/2024

DOI: 10.1016/j.jss.2024.04.027

PMID: 38759329

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Abstract

Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphate levels and outcomes in liver resections. We performed a retrospective analysis of liver resections performed at our institution. Patients were categorized based on preoperative phosphate levels (low versus normal). Our primary outcome measure was posthepatectomy liver failure. A total of 265 cases met the study criteria. 71 patients (26.7%) had low preoperative phosphate levels. The incidence of posthepatectomy liver failure was higher in the low preoperative phosphate group (19.2% versus 12.4%). However, after propensity score matching, rates of posthepatectomy liver failure were similar between low and normal preoperative phosphate cohorts (13% versus 14%, P = 0.83). Low preoperative phosphate levels were not associated with worse postoperative outcomes in this study. Further studies are warranted to investigate this association and its relevance as a clinical prognostic factor for postoperative liver failure.

Liver regeneration

Liver resection

Posthepatectomy liver failure

Preoperative hypophosphatemia

Surgical outcomes

Details

Title: Subtitle: The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience
Creators: Erik S. Davis - University of Iowa
Peyton Seda - University of Iowa
David Turaczyk Kolodziej - University of Iowa, Surgery
Aneli T. Villa - University of Iowa
Lawrence Feng - University of Iowa
Olivia DiGioia - University of Iowa
Apoorve Nayyar - University of Iowa
Faisal S. Jehan - Roswell Park Comprehensive Cancer Center
Hassan Aziz - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: The Journal of surgical research, Vol.299, pp.145-150
Publisher: Elsevier Inc; SAN DIEGO
DOI: 10.1016/j.jss.2024.04.027
PMID: 38759329
ISSN: 0022-4804
eISSN: 1095-8673
Number of pages: 6
Language: English
Date published: 07/01/2024
Academic Unit: Surgery; Otolaryngology; Internal Medicine
Record Identifier: 9984701645902771

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