Journal article
The Association between Metabolic Syndrome, Frailty and Disability-Free Survival in Healthy Community-dwelling Older Adults
The Journal of nutrition, health & aging, Vol.27(1), pp.1-9
01/2023
DOI: 10.1007/s12603-022-1860-2
PMCID: PMC10061371
PMID: 36651481
Abstract
Objectives To examine the association between metabolic syndrome (MetS) and frailty, and determine whether co-existent MetS and frailty affect disability-free survival (DFS), assessed through a composite of death, dementia or physical disability. Design Longitudinal study. Setting and Participants Community-dwelling older adults from Australia and the United States (n=18,264) from "ASPirin in Reducing Events in the Elderly" (ASPREE) study. Measurements MetS was defined according to American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (2018). A modified Fried phenotype and a deficit accumulation Frailty Index (FI) were used to assess frailty. Association between MetS and frailty was examined using multinomial logistic regression. Cox regression was used to analyze the association between MetS, frailty and DFS over a median follow-up of 4.7 years. Results Among 18,264 participants, 49.9% met the criteria for MetS at baseline. Participants with Mets were more likely to be pre-frail [Relative Risk Ratio (RRR): 1.22; 95%Confidence Interval (CI): 1.14, 1.30)] or frail (RRR: 1.66; 95%CI: 1.32, 2.08) than those without MetS. MetS alone did not shorten DFS while pre-frailty or frailty alone did [Hazard Ratio (HR): 1.68; 95%CI: 1.45, 1.94; HR: 2.65; 95%CI:1.92, 3.66, respectively]. Co-existent MetS with pre-frailty/frailty did not change the risk of shortened DFS. Conclusions MetS was associated with pre-frailty or frailty in community-dwelling older individuals. Pre-frailty or frailty increased the risk of reduced DFS but presence of MetS did not change this risk. Assessment of frailty may be more important than MetS in predicting survival free of dementia or physical disability.
Details
- Title: Subtitle
- The Association between Metabolic Syndrome, Frailty and Disability-Free Survival in Healthy Community-dwelling Older Adults
- Creators
- A. R. M. Saifuddin Ekram - Australian Regenerative Medicine InstituteS. E. Espinoza - Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USAM. E. Ernst - University of IowaJ. Ryan - Monash UniversityL. Beilin - The University of Western AustraliaN. P. Stocks - The University of AdelaideS. A. Ward - Monash UniversityJ. J. McNeil - Monash UniversityR. C. Shah - Rush UniversityR. L. Woods - Monash University
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, health & aging, Vol.27(1), pp.1-9
- DOI
- 10.1007/s12603-022-1860-2
- PMID
- 36651481
- PMCID
- PMC10061371
- NLM abbreviation
- J Nutr Health Aging
- ISSN
- 1279-7707
- eISSN
- 1760-4788
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) U01AG029824; U19AG062682 / National Cancer Institute at the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Victorian Cancer Agency APP1135727 / National Health and Medical Research Council Research Leader Fellowship; National Health and Medical Research Council (NHMRC) of Australia 334047; 1127060 / National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia Monash University
- Language
- English
- Electronic publication date
- 11/14/2022
- Date published
- 01/2023
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984327056502771
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