Journal article
The Association of Sleep Duration and Sleep Efficiency with Amyloid β Accumulation Among Cognitively Healthy Later Life Adults: A Systematic Review
Alzheimer's & dementia, Vol.18(S11), e063877
12/2022
DOI: 10.1002/alz.063877
Abstract
Background
Amyloid β(Aβ) accumulation is a hallmark of the progressive neurodegenerative Alzheimer’s Disease (AD). Disruptions in sleep beyond aging are found to be risk factors of developing AD because sleep may involves in Aβ level regulations, neurotoxin clearance, or inflammation process. Sleep disruptions can be defined by shorter sleep duration and lower sleep efficiency. This systematic review examines how sleep duration and efficiency are associated with amyloid deposition in later life adults.
Method
We screened 3,122 published articles searched from electronic databases (i.e., PubMed, CINAHL, Embase, and PsycINFO) and used 14 articles for the qualitative synthesis. All articles met the eligibility criteria including published articles that contain sleep duration and efficiency measure, Aβ measure, human studies with cognitively normal older adults who are 50 and above.
Result
Studies were conducted in the United States, Italy, South Korea, China, and Australia. Of the 14 studies included, 12 used a cross‐sectional design and 2 used a longitudinal design. Sample sizes ranged from 13 to 4,772. Ages of the samples ranged from 50 to 85. Studies measured Aβ using cerebrospinal fluid, serum, and Positron Emission Tomography (PET) scans with two different tracers: C‐labeled Pittsburgh compound B or fluorine 18–labeled (18F). Sleep duration and efficiency were subjectively measured using interviews and questionnaires, or objective measures, such as polysomnography or actigraphy. Studies accounted for demographic and lifestyle factors in their analyses, such as age, sex, family history, sleep, habitual alcohol consumption, slow wave sleep, apnea hypopnea index, exercise, fasting glucose, and triglycerides. Only 3 of the 14 studies indicated that sleep duration was associated with Aβ accumulation, and 4 of the studies revealed that sleep efficiency was associated with Aβ accumulation.
Conclusion
This review suggests that previous studies have provided mixed evidence regarding the relationship between sleep duration and Aβ or the relationship between sleep efficiency and Aβ. Not all studies used a sufficient sample size or a comprehensive measurement of sleep. These results indicate the need for more future studies using a longitudinal design, comprehensive sleep measure, and larger sample sizes to advance understanding the relationship between sleep and Aβ.
Details
- Title: Subtitle
- The Association of Sleep Duration and Sleep Efficiency with Amyloid β Accumulation Among Cognitively Healthy Later Life Adults: A Systematic Review
- Creators
- Chooza Moon - University of Iowa College of NursingAaron Schneider - University of IowaMeina Zhang - University of IowaYoung‐Eun Cho - The University of Iowa College of NursingHellen Dang - University of Iowa College of Liberal Arts and SciencesKelly H Vu - University of Iowa College of Pharmacy
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.18(S11), e063877
- DOI
- 10.1002/alz.063877
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Number of pages
- 1
- Language
- English
- Date published
- 12/2022
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology
- Record Identifier
- 9984339459302771
Metrics
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