The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels

Christopher S Coffey; Folkert W Asselbergs; Patricia R Hebert; Hans L Hillege; Qing Li; Jason H Moore; Wiek H van Gilst

doi:10.4061/2011/541467

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The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels

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The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels

Christopher S Coffey, Folkert W Asselbergs, Patricia R Hebert, Hans L Hillege, Qing Li, Jason H Moore and Wiek H van Gilst

Cardiology research and practice, Vol.2011(1), pp.1-8

2011

DOI: 10.4061/2011/541467

PMCID: PMC3087975

PMID: 21559217

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Abstract

Background. We used a random sample (n=2,495) from the population-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study population to examine the association of the metabolic syndrome (Met S) with plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) antigen levels.Results. The overall prevalence of the Met S was 18%, was dependent on age and gender, and was positively associated with higher antigen levels of both PAI-1 and t-PA. These significant effects were maintained after adjustment for age, gender, BMI, elevated C-reactive protein, smoking status, urinary albumin excretion, and insulin levels. We found no significant interactions between the Met S and other covariates on PAI-1 and t-PA levels.Conclusions. Our study demonstrates that those with the Met S have significantly higher levels of PAI-1 and t-PA antigen, factors known to increase the risk of cardiovascular disease.

Details

Title: Subtitle: The Association of the Metabolic Syndrome with PAI-1 and t-PA Levels
Creators: Christopher S Coffey - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Folkert W Asselbergs - Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Patricia R Hebert - Charles E. Schmidt College of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
Hans L Hillege - Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Qing Li - Clinical Affairs and Medical Communications, ConvaTec, Inc., Skillman, NJ 08558, USA
Jason H Moore - Departments of Genetics and Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Wiek H van Gilst - Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Resource Type: Journal article
Publication Details: Cardiology research and practice, Vol.2011(1), pp.1-8
DOI: 10.4061/2011/541467
PMID: 21559217
PMCID: PMC3087975
NLM abbreviation: Cardiol Res Pract
ISSN: 2090-0597
eISSN: 2090-0597
Grant note: DOI: 10.13039/100000002, name: Netherlands Kidney Foundation, award: E.013, HL65234, HL67466, RR018787, LM010098
Language: English
Date published: 2011
Academic Unit: Biostatistics
Record Identifier: 9984214670402771

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