Journal article
The Bal I and Msp I polymorphisms in the dopamine D3 receptor gene display, linkage disequilibrium with each other but no association with Tourette syndrome
Psychiatric genetics, Vol.8(2), pp.49-52
01/01/1998
DOI: 10.1097/00041444-199800820-00003
Abstract
The D3-dopamine receptor gene, DRD3, has been considered as a candidate gene in several disorders in which the dopaminergic system has been implicated including Tourette syndrome and schizophrenia. The DRD3 studies to date have all used as the gene marker a Bal I polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). There have been recent reports on a second marker, an Msp I PCR RFLP, that lies 40 kb downstream. We have typed a sample of 16 Tourette syndrome families with both markers and observed significant linkage disequilibrium between the two markers but no apparent association of either marker with Tourette syndrome.
Details
- Title: Subtitle
- The Bal I and Msp I polymorphisms in the dopamine D3 receptor gene display, linkage disequilibrium with each other but no association with Tourette syndrome
- Creators
- E J Devor - University of IowaR. M. Dill-DevorH. J. Magee
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.8(2), pp.49-52
- DOI
- 10.1097/00041444-199800820-00003
- ISSN
- 0955-8829
- Language
- English
- Date published
- 01/01/1998
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557410902771
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