The Berlin questionnaire screens for obstructive sleep apnea in idiopathic intracranial hypertension

Matthew J Thurtell; Beau B Bruce; David B Rye; Nancy J Newman; Valerie Biousse

doi:10.1097/WNO.0b013e31821a4d54

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The Berlin questionnaire screens for obstructive sleep apnea in idiopathic intracranial hypertension

Journal article

Open access

Peer reviewed

The Berlin questionnaire screens for obstructive sleep apnea in idiopathic intracranial hypertension

Matthew J Thurtell, Beau B Bruce, David B Rye, Nancy J Newman and Valerie Biousse

Journal of neuro-ophthalmology, Vol.31(4), pp.316-319

12/2011

DOI: 10.1097/WNO.0b013e31821a4d54

PMCID: PMC3433717

PMID: 21537196

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Abstract

Obstructive sleep apnea (OSA) may be associated with idiopathic intracranial hypertension (IIH), a disorder most commonly occurring in young obese women. Because polysomnography, the standard test for diagnosing OSA, is expensive and time consuming, questionnaires have been developed to identify persons with OSA. The Berlin questionnaire (BQ) reliably identifies middle-aged and older persons in the community who are at high-risk for OSA. We aimed to validate the BQ as a screening tool for OSA in IIH patients. Patients with newly diagnosed IIH completed the BQ and then underwent diagnostic polysomnography. The BQ was scored as high or low risk for OSA, and the diagnosis of OSA was based on polysomnography findings. OSA was defined as an apnea-hypopnea index of ≥ 5 on polysomnography. Thirty patients were evaluated (24 women; 15 white and 15 black; age, 16-54 years [median, 32 years]; body mass index, 27.3-51.7 kg/m2 [median, 39.8 kg/m2]). Twenty patients (66.7%) had a high-risk BQ score and 18 (60%) exhibited OSA. Fifteen of 20 (75%) with a high-risk BQ score had OSA, while 3 of 10 (30%) with a low-risk score had OSA (Fisher test, P = 0.045). The sensitivity and specificity of the BQ for OSA in IIH patients were 83% and 58%, respectively, whereas the positive predictive value was 75%. A low-risk BQ score identifies IIH patients who are unlikely to have OSA. Polysomnography should be considered in those with a high-risk score.

Body Mass Index

Predictive Value of Tests

Reproducibility of Results

Humans

Middle Aged

Pseudotumor Cerebri - diagnosis

Male

False Positive Reactions

Polysomnography

Young Adult

Sensitivity and Specificity

Adolescent

Adult

Female

Surveys and Questionnaires

Sleep Apnea, Obstructive - diagnosis

Details

Title: Subtitle: The Berlin questionnaire screens for obstructive sleep apnea in idiopathic intracranial hypertension
Creators: Matthew J Thurtell - Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, USA
Beau B Bruce
David B Rye
Nancy J Newman
Valerie Biousse
Resource Type: Journal article
Publication Details: Journal of neuro-ophthalmology, Vol.31(4), pp.316-319
DOI: 10.1097/WNO.0b013e31821a4d54
PMID: 21537196
PMCID: PMC3433717
NLM abbreviation: J Neuroophthalmol
ISSN: 1070-8022
eISSN: 1536-5166
Publisher: United States
Grant note: P30-EY06360 / NEI NIH HHS KL2 RR025009 / NCRR NIH HHS UL1 TR000454 / NCATS NIH HHS NS055015 / NINDS NIH HHS R01 NS055015 / NINDS NIH HHS R01 MH083746 / NIMH NIH HHS L30 EY019180 / NEI NIH HHS KL2 TR000455 / NCATS NIH HHS K23-EY019341 / NEI NIH HHS K23 EY019341 / NEI NIH HHS UL1 RR025008 / NCRR NIH HHS P30 EY006360 / NEI NIH HHS UL1-RR025008 / NCRR NIH HHS MH083746 / NIMH NIH HHS KL2-RR025009 / NCRR NIH HHS
Language: English
Date published: 12/2011
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983980061202771

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