Journal article
The Biodistribution of [153Gd]Gd-Labeled Magnetic Resonance Contrast Agents in a Transgenic Mouse Model of Renal Failure Differs Greatly from Control Mice
Magnetic resonance in medicine, Vol.64(5), pp.1274-1280
11/01/2010
DOI: 10.1002/mrm.22553
PMCID: PMC3180881
PMID: 20648683
Abstract
Nephrogenic Systemic Fibrosis (NSF) occurs in renally impaired patients who have undergone contrast enhanced MR examination using intravenous gadolinium (Gd)-based contrast agents. The effect of impaired kidney function on the biodistribution of Gd-based contrast agents was investigated using radiolabeled
153/Nat
Gd-DOTA,
153/Nat
Gd-DTPA and
153/Nat
Gd-DTPA-BMA in a transgenic mouse model of renal impairment. Renally impaired (RI) animals had more activity associated with their tissues than did control mice, and this increase varied according to the radiotracer injected. For example, after 7 days, RI animals that received
153/Nat
Gd-DOTA had 3-fold (p < 0.037) more activity in their bone tissue while RI animals receiving
153/Nat
Gd-DTPA and
153/Nat
Gd-DTPA-BMA had 8-fold (p < 0.0001) and 24-fold (p < 0.0001) more activity in their bone tissue, respectively. These findings demonstrate that renal impairment dramatically alters the tissue distribution of Gd
3+
ions
in vivo
, which are likely a critical factor in the development of NSF.
Details
- Title: Subtitle
- The Biodistribution of [153Gd]Gd-Labeled Magnetic Resonance Contrast Agents in a Transgenic Mouse Model of Renal Failure Differs Greatly from Control Mice
- Creators
- Thaddeus J. Wadas - MallinckrodtChristopher D. Sherman - MallinckrodtJeffrey H. Miner - Washington University in St. LouisJames R. Duncan - MallinckrodtCarolyn J. Anderson - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.64(5), pp.1274-1280
- DOI
- 10.1002/mrm.22553
- PMID
- 20648683
- PMCID
- PMC3180881
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Grant note
- P30 DK079333-05 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK
- Language
- English
- Date published
- 11/01/2010
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984313068802771
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