Journal article
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions
Development (Cambridge), Vol.133(14), pp.2747-2756
07/2006
DOI: 10.1242/dev.02447
PMID: 16774992
Abstract
In the nematode Caenorhabditis elegans, neurons are generated from asymmetric divisions in which a mother cell divides to produce daughters that differ in fate. Here, we demonstrate that the gene pig-1 regulates the asymmetric divisions of neuroblasts that divide to produce an apoptotic cell and either a neural precursor or a neuron. In pig-1 mutants, these neuroblasts divide to produce daughters that are more equal in size, and their apoptotic daughters are transformed into their sisters, leading to the production of extra neurons. PIG-1 is orthologous to MELK, a conserved member of the polarity-regulating PAR-1/Kin1/SAD-1 family of serine/threonine kinases. Although MELK has been implicated in regulating the cell cycle, our data suggest that PIG-1, like other PAR-1 family members, regulates cell polarity.
Details
- Title: Subtitle
- The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions
- Creators
- Shaun Cordes - Molecular and Cell Biology, University of California, Berkeley, CA 94720, USAC Andrew FrankGian Garriga
- Resource Type
- Journal article
- Publication Details
- Development (Cambridge), Vol.133(14), pp.2747-2756
- DOI
- 10.1242/dev.02447
- PMID
- 16774992
- NLM abbreviation
- Development
- ISSN
- 0950-1991
- eISSN
- 1477-9129
- Publisher
- England
- Grant note
- NS42213 / NINDS NIH HHS
- Language
- English
- Date published
- 07/2006
- Academic Unit
- Anatomy and Cell Biology; Iowa Neuroscience Institute
- Record Identifier
- 9984025462002771
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