Journal article
The CD4 T cell response to respiratory syncytial virus infection
Immunologic research, Vol.59(1), pp.109-117
08/2014
DOI: 10.1007/s12026-014-8540-1
PMID: 24838148
Abstract
Respiratory syncytial virus (RSV) can induce severe lower respiratory tract infections in infants and is the leading cause of bronchiolitis in children worldwide. RSV-induced inflammation is believed to contribute substantially to the severity of disease. T helper (Th)2-, Th9-, and Th17-related cytokines are all observed in infants hospitalized following a severe RSV infection. These cytokines cause an influx of inflammatory cells, resulting in mucus production and reduced lung function. Consistent with the data from RSV-infected infants, CD4 T cell production of Interleukin (IL)-9, IL-13, and IL-17 has all been shown to contribute to RSV-induced disease in a murine model of RSV infection. Conversely, murine studies indicate that the combined actions of regulatory factors such as CD4 regulatory T cells and IL-10 inhibit the inflammatory cytokine response and limit RSV-induced disease. In support of this, IL-10 polymorphisms are associated with susceptibility to severe disease in infants. Insufficient regulation and excess inflammation not only impact disease following primary RSV infection it can also have a major impact following vaccination. Prior immunization with a formalin-inactivated (FI-RSV) vaccine resulted in enhanced disease in infants following a natural RSV infection. A Th2 CD4 T cell response has been implicated to be a major contributor in mediating vaccine-enhanced disease. Thus, future RSV vaccines must induce a balanced CD4 T cell response in order to facilitate viral clearance while inducing proper regulation of the immune response.
Details
- Title: Subtitle
- The CD4 T cell response to respiratory syncytial virus infection
- Creators
- Allison Christiaansen - Department of Microbiology University of Iowa 51 Newton Road, 3-532 BSB Iowa City IA 52242 USACory Knudson - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA 52242 USAKayla Weiss - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA 52242 USASteven Varga - Department of Pathology University of Iowa Iowa City IA 52242 USA
- Contributors
- Gail A Bishop (Editor)
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1), pp.109-117
- DOI
- 10.1007/s12026-014-8540-1
- PMID
- 24838148
- NLM abbreviation
- Immunol Res
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Publisher
- Springer US
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; President; Pathology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984083888402771
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