Journal article
The CD40–CD154 interaction in B cell–T cell liaisons
Cytokine & growth factor reviews, Vol.14(3), pp.297-309
2003
DOI: 10.1016/S1359-6101(03)00024-8
PMID: 12787567
Abstract
The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides important signals regulating clonal expansion, antibody production and isotype switching, as well as the development of humoral memory. The major source of CD154, the ligand for CD40, is activated T lymphocytes. Interactions between CD40 and CD154 provide a number of signals that play important roles in regulating the complex and multifactorial interactions between these two major cell types of the adaptive immune response. Understanding both the biological effects of this receptor–ligand interaction, as well as how CD40 signaling pathways are controlled, adds to our detailed picture of the complex interplay between B and T cells.
Details
- Title: Subtitle
- The CD40–CD154 interaction in B cell–T cell liaisons
- Creators
- Gail A Bishop - Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USABruce S Hostager - Department of Pediatrics, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cytokine & growth factor reviews, Vol.14(3), pp.297-309
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S1359-6101(03)00024-8
- PMID
- 12787567
- ISSN
- 1359-6101
- eISSN
- 1879-0305
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001114702771
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