Journal article
The CEPH consortium linkage map of human chromosome 1
Genomics (San Diego, Calif.), Vol.9(4), pp.686-700
1991
DOI: 10.1016/0888-7543(91)90362-I
PMID: 2037294
Abstract
This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 α-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals > 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM.
Details
- Title: Subtitle
- The CEPH consortium linkage map of human chromosome 1
- Creators
- Nicholas C Dracopoli - Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USAPeter O'Connell - Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City, Utah 84132, USATami I Elsner - Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City, Utah 84132, USAJean-Marc Lalouel - Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City, Utah 84132, USARaymond L White - Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City, Utah 84132, USAKenneth H Buetow - Fox Chase Cancer Center Philadelphia, Pennsylvania 19111, USADarryl Y Nishimura - Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USAJeffrey C Murray - Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USACynthia Helms - Department of Genetics, Washington University, St. Louis, Missouri 63110, USASantosh K Mishra - Department of Genetics, Washington University, St. Louis, Missouri 63110, USAHelen Donis-Keller - Department of Genetics, Washington University, St. Louis, Missouri 63110, USAJeffrey M Hall - School of Public Health, University of California, Berkeley, California 94720, USAMing K Lee - School of Public Health, University of California, Berkeley, California 94720, USAMary-Claire King - School of Public Health, University of California, Berkeley, California 94720, USAJohn Attwood - The Galton Laboratory, University College London, London NW1 2HE, EnglandNewton E Morton - Department of Community Medicine, University of Southampton, Southampton S09 4XY, EnglandElizabeth B Robson - The Galton Laboratory, University College London, London NW1 2HE, EnglandMelanie Mahtani - Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USAHuntington F Willard - Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USANicola J Royle - Department of Genetics, University of Leicester, Leicester LE1 7RH, EnglandIla Patel - Department of Genetics, University of Leicester, Leicester LE1 7RH, EnglandAlec J Jeffreys - Department of Genetics, University of Leicester, Leicester LE1 7RH, EnglandVera Verga - MRC Human Ecogenetics Research Unit, Department of Human Genetics, South African Institute for Medical Research, Johannesburg 2000, South AfricaTrefor Jenkins - MRC Human Ecogenetics Research Unit, Department of Human Genetics, South African Institute for Medical Research, Johannesburg 2000, South AfricaJames L Weber - Marshfield Medical Research Foundation, Marshfield, Wisconsin 54449, USAAnna L Mitchell - Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510 USAAllen E Bale - Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510 USA
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.9(4), pp.686-700
- DOI
- 10.1016/0888-7543(91)90362-I
- PMID
- 2037294
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1991
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Ophthalmology and Visual Sciences
- Record Identifier
- 9984025564302771
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