Journal article
The CXC-chemokine, Hi74: expression in the central nervous system
Journal of neurovirology, Vol.4(6), pp.575-585
1998
DOI: 10.3109/13550289809114224
Abstract
H174 is a new member of the CXC-chemokine family. A cDNA probe containing the entire H174 coding region recognized a predominant inducible transcript of approximately 1.5 kb expressed in interferon (IFN) activated astrocytoma and monocytic cell lines. Hi74 message can be induced following IFN-α IFN-β or IFN-γ stimulation. H174 message was also detected in IFN treated cultures of primary human astrocytes, but was absent in unstimulated astrocytes. H174, like IP10 and Mig, lacks the ELR sequence associated with the neutrophil specificity characteristic of most CXC-chemokines. Preliminary experiments suggest H174, IP10 and Mig are independently regulated. Recombinant H174 is a weak chemoattractant for monocyte-like cells. H174 can also stimulate calcium flux responses. The data support the classification of H174 as a member of a subfamily of interferon-γ inducible non-ELR CXC-chemokines. Brain tissues were obtained at autopsy from one patient with AIDS dementia, one patient with multiple sclerosis, and two normal control patients. H174 and Mig were detected by RT-PCR in brain tissue cDNA derived from the patients with pathological conditions associated with activated astrocytes but not in cDNA from control specimens.
Details
- Title: Subtitle
- The CXC-chemokine, Hi74: expression in the central nervous system
- Creators
- Yi Luo - Harvard UniversityRobert Kim - Harvard Medical SchoolDana Gabuzda - Harvard Medical SchoolSha Mi - Harvard Medical SchoolLisa A Collins-Racie - Harvard Medical SchoolZhijian Lu - Harvard Medical SchoolKenneth A Jacobs - Harvard Medical SchoolMartin E Dorf - Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Journal of neurovirology, Vol.4(6), pp.575-585
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/13550289809114224
- ISSN
- 1355-0284
- eISSN
- 1538-2443
- Language
- English
- Date published
- 1998
- Academic Unit
- Urology
- Record Identifier
- 9984319974102771
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