Journal article
The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity
The Journal of immunology (1950), Vol.211(5), pp.711-719
09/01/2023
DOI: 10.4049/jimmunol.2300171
PMCID: PMC10449360
PMID: 37603859
Abstract
The immunological hallmarks of sepsis include the inflammation-mediated cytokine storm, apoptosis-driven lymphopenia, and prolonged immunoparalysis. Although early clinical efforts were focused on increasing the survival of patients through the first phase, studies are now shifting attention to the long-term effects of sepsis on immune fitness in survivors. In particular, the most pertinent task is deciphering how the immune system becomes suppressed, leading to increased incidence of secondary infections. In this review, we introduce the contribution of numerical changes and functional reprogramming within innate (NK cells, dendritic cells) and adaptive (T cells, B cells) immune cells on the chronic immune dysregulation in the septic murine and human host. We briefly discuss how prior immunological experience in murine models impacts sepsis severity, immune dysfunction, and clinical relevance. Finally, we dive into how comorbidities, specifically autoimmunity and cancer, can influence host susceptibility to sepsis and the associated immune dysfunction.
Details
- Title: Subtitle
- The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity
- Creators
- Elvia E Silva - University of IowaCara Skon-Hegg - University of MinnesotaVladimir P Badovinac - University of IowaThomas S Griffith - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.211(5), pp.711-719
- DOI
- 10.4049/jimmunol.2300171
- PMID
- 37603859
- PMCID
- PMC10449360
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- DOI: 10.13039/100015691, name: HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, award: AI007511; DOI: 10.13039/100000057, name: HHS | NIH | National Institute of General Medical Sciences, award: GM134880; DOI: 10.13039/100000060, name: HHS | NIH | National Institute of Allergy and Infectious Diseases, award: AI114543; DOI: 10.13039/100000057, name: HHS | NIH | National Institute of General Medical Sciences, award: GM140881; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: BX001324; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: BX006192
- Language
- English
- Date published
- 09/01/2023
- Academic Unit
- Pathology; Internal Medicine
- Record Identifier
- 9984455946702771
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