Journal article
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Cell reports (Cambridge), Vol.23(1), pp.313-326.e5
04/03/2018
DOI: 10.1016/j.celrep.2018.03.075
PMCID: PMC6075733
PMID: 29617669
Abstract
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.
Details
- Title: Subtitle
- The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
- Creators
- Christopher J Ricketts - National Cancer InstituteAguirre A De Cubas - Vanderbilt UniversityHuihui Fan - Van Andel InstituteChristof C Smith - University of North Carolina at Chapel HillMartin Lang - National Cancer InstituteEd Reznik - Memorial Sloan Kettering Cancer CenterReanne Bowlby - Canada's Michael Smith Genome Sciences CentreEwan A Gibb - Canada's Michael Smith Genome Sciences CentreRehan Akbani - The University of Texas MD Anderson Cancer CenterRameen Beroukhim - Massachusetts Institute of TechnologyDonald P Bottaro - National Cancer InstituteToni K Choueiri - Harvard UniversityRichard A Gibbs - Baylor College of MedicineAndrew K Godwin - University of KansasScott Haake - Vanderbilt UniversityA Ari Hakimi - Memorial Sloan Kettering Cancer CenterElizabeth P Henske - Brigham and Women's HospitalJames J Hsieh - Washington University in St. LouisThai H Ho - Mayo ClinicRupa S Kanchi - The University of Texas MD Anderson Cancer CenterBhavani Krishnan - University of North Carolina at Chapel HillDavid J Kwiatkowski - Brigham and Women's HospitalWembin Lui - The University of Texas MD Anderson Cancer CenterMaria J Merino - National Cancer InstituteGordon B Mills - The University of Texas MD Anderson Cancer CenterJerome Myers - Centura Health, Centennial, CO 80112, USA.Michael L Nickerson - National Cancer InstituteVictor E Reuter - Memorial Sloan Kettering Cancer CenterLaura S Schmidt - National Cancer InstituteC Simon Shelley - Leukemia Therapeutics LLC., Hull, MA 02045, USA.Hui Shen - Van Andel InstituteBrian Shuch - Yale UniversitySabina Signoretti - Harvard UniversityRamaprasad Srinivasan - National Cancer InstitutePheroze Tamboli - The University of Texas MD Anderson Cancer CenterGeorge Thomas - Oregon Health & Science UniversityBenjamin G Vincent - University of North Carolina at Chapel HillCathy D Vocke - National Cancer InstituteDavid A Wheeler - Baylor College of MedicineLixing Yang - Harvard UniversityWilliam Y Kim - University of North Carolina at Chapel HillA Gordon Robertson - Canada's Michael Smith Genome Sciences CentrePaul T Spellman - Oregon Health & Science UniversityW Kimryn Rathmell - Vanderbilt UniversityW Marston Linehan - National Cancer Institute
- Contributors
- Cancer Genome Atlas Research Network (Contributor)Deqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.23(1), pp.313-326.e5
- DOI
- 10.1016/j.celrep.2018.03.075
- PMID
- 29617669
- PMCID
- PMC6075733
- NLM abbreviation
- Cell Rep
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- U24 CA143843 / NCI NIH HHS R01 CA169172 / NCI NIH HHS P30 CA016086 / NCI NIH HHS U24 CA210957 / NCI NIH HHS U54 HG003079 / NHGRI NIH HHS P30 CA016672 / NCI NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS K24 CA172355 / NCI NIH HHS HHSN261200800001C / CCR NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U24 CA143882 / NCI NIH HHS K12 CA090625 / NCI NIH HHS P30 CA008748 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA143840 / NCI NIH HHS U24 CA144025 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA210949 / NCI NIH HHS U24 CA143848 / NCI NIH HHS R01 CA163722 / NCI NIH HHS HHSN261200800001E / NCI NIH HHS
- Language
- English
- Date published
- 04/03/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984185168102771
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