Journal article
The Cancer Genome Atlas expression profiles of low-grade gliomas
Neurosurgical focus, Vol.36(4), pp.E23-E23
04/2014
DOI: 10.3171/2012.12.FOCUS12351
PMID: 24812719
Abstract
Differentiating between low-grade gliomas (LGGs) of astrocytic and oligodendroglial origin remains a major challenge in neurooncology. Here the authors analyzed The Cancer Genome Atlas (TCGA) profiles of LGGs with the goal of identifying distinct molecular characteristics that would afford accurate and reliable discrimination of astrocytic and oligodendroglial tumors. They found that 1) oligodendrogliomas are more likely to exhibit the glioma-CpG island methylator phenotype (G-CIMP), relative to low-grade astrocytomas; 2) relative to oligodendrogliomas, low-grade astrocytomas exhibit a higher expression of genes related to mitosis, replication, and inflammation; and 3) low-grade astrocytic tumors harbor microRNA profiles similar to those previously described for glioblastoma tumors. Orthogonal intersection of these molecular characteristics with existing molecular markers, such as IDH1 mutation, TP53 mutation, and 1p19q status, should facilitate accurate and reliable pathological diagnosis of LGGs.
Details
- Title: Subtitle
- The Cancer Genome Atlas expression profiles of low-grade gliomas
- Creators
- David D Gonda - 1Departments of Neurosurgery andVincent J Cheung - 1Departments of Neurosurgery andKarra A Muller - 2Neuropathology, University of California, San Diego, CaliforniaAmit Goyal - 1Departments of Neurosurgery andBob S Carter - 1Departments of Neurosurgery andClark C Chen - 1Departments of Neurosurgery and
- Resource Type
- Journal article
- Publication Details
- Neurosurgical focus, Vol.36(4), pp.E23-E23
- DOI
- 10.3171/2012.12.FOCUS12351
- PMID
- 24812719
- ISSN
- 1092-0684
- eISSN
- 1092-0684
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Pathology
- Record Identifier
- 9984047684202771
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