The Carbon Isotope Ratios of Serum Amino Acids in Combination with Participant Characteristics can be Used to Estimate Added Sugar Intake in a Controlled Feeding Study of US Postmenopausal Women

Hee Young Yun; Lesley F Tinker; Marian L Neuhouser; Dale A Schoeller; Yasmin Mossavar-Rahmani; Linda G Snetselaar; Linda V Van Horn; Charles B Eaton; Ross L Prentice; Johanna W Lampe; Diane M O'Brien

doi:10.1093/jn/nxaa195

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The Carbon Isotope Ratios of Serum Amino Acids in Combination with Participant Characteristics can be Used to Estimate Added Sugar Intake in a Controlled Feeding Study of US Postmenopausal Women

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The Carbon Isotope Ratios of Serum Amino Acids in Combination with Participant Characteristics can be Used to Estimate Added Sugar Intake in a Controlled Feeding Study of US Postmenopausal Women

Hee Young Yun, Lesley F Tinker, Marian L Neuhouser, Dale A Schoeller, Yasmin Mossavar-Rahmani, Linda G Snetselaar, Linda V Van Horn, Charles B Eaton, Ross L Prentice, Johanna W Lampe, …

The Journal of nutrition, Vol.150(10), pp.2764-2771

10/12/2020

DOI: 10.1093/jn/nxaa195

PMCID: PMC7549297

PMID: 32712658

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Abstract

The carbon isotope ratio (CIR) is a proposed biomarker for added sugar (AS) intake in the United States; however, because the CIR is also associated with meat intake in most populations the need for specificity remains. The CIR of amino acids (AAs) has the potential to differentiate sugars from meat intakes, because essential AAs must derive from dietary protein whereas certain nonessential AAs can be synthesized from sugars. We tested whether serum CIR-AAs in combination with participant characteristics could meet a prespecified biomarker criterion for AS intake in the Nutrition and Physical Activity Assessment Study Feeding Study (NPAAS-FS) of the Women's Health Initiative, a population in which the whole-serum CIR was not associated with AS intake. Postmenopausal women (n = 145) from Seattle, WA, were provided with individualized diets that approximated their habitual food intakes for 2 wk. Dietary intakes from consumed foods were characterized over the feeding period using the Nutrition Data System for Research. The CIR of 7 AAs-Ala, Gly, Val, Leu, Ile, Pro, and Phe-were measured in fasting serum collected at the end of the 2-wk feeding period, using gas chromatography-combustion isotope ratio mass spectrometry. Biomarker models were evaluated using regression R2 ≥ 0.36 as a major biomarker criterion, based on the benchmark R2 values of well-established recovery biomarkers in the NPAAS-FS. AS intake was associated with CIR-Ala (ρ = 0.32; P < 0.0001). A model of AS intake based on CIR-Ala, CIR-Gly, CIR-Ile, smoking, leisure physical activity, and body weight met the biomarker criterion (R2 = 0.37). Biomarker-estimated AS intake was not associated with meat or animal protein intake. Results support serum CIR-AAs in combination with participant characteristics as potential biomarkers of AS intake in US populations, including those with low AS intake.The Women's Health Initiative is registered at clinicaltrials.gov (NCT00000611).

Aged

Amino Acids - blood

Biomarkers - blood

Carbon Isotopes - blood

Diet

Dietary Sugars - administration & dosage

Dietary Sugars - metabolism

Feeding Behavior

Female

Humans

Nutritional Physiological Phenomena

Nutritional Status

Postmenopause

United States

Details

Title: Subtitle: The Carbon Isotope Ratios of Serum Amino Acids in Combination with Participant Characteristics can be Used to Estimate Added Sugar Intake in a Controlled Feeding Study of US Postmenopausal Women
Creators: Hee Young Yun - Center for Alaska Native Health Research, Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA
Lesley F Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Marian L Neuhouser - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Dale A Schoeller - Department of Nutritional Sciences, University of Wisconsin, Madison, WI, USA
Yasmin Mossavar-Rahmani - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY, USA
Linda G Snetselaar - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Linda V Van Horn - Department of Preventive Medicine, Northwestern University, Chicago, IL, USA
Charles B Eaton - Department of Family Medicine, Alpert Medical School, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA
Ross L Prentice - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Johanna W Lampe - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Diane M O'Brien - Center for Alaska Native Health Research, Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA
Resource Type: Journal article
Publication Details: The Journal of nutrition, Vol.150(10), pp.2764-2771
DOI: 10.1093/jn/nxaa195
PMID: 32712658
PMCID: PMC7549297
NLM abbreviation: J Nutr
ISSN: 0022-3166
eISSN: 1541-6100
Grant note: R01 CA119171 / NCI NIH HHS HHSN268201600003C / NHLBI NIH HHS R21 CA182674 / NCI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS P30 CA015704 / NCI NIH HHS HHSN268201600001C / NHLBI NIH HHS P30 GM103325 / NIGMS NIH HHS P30 CA023074 / NCI NIH HHS HHSN271201600004C / NIDA NIH HHS R01 DK109946 / NIDDK NIH HHS
Language: English
Date published: 10/12/2020
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215140502771

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