The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group

Cheryl E Gariepy; Melvin B Heyman; Mark E Lowe; John F Pohl; Steven L Werlin; Michael Wilschanski; Bradley Barth; Douglas S Fishman; Steven D Freedman; Matthew J Giefer; Tanja Gonska; Ryan Himes; Sohail Z Husain; Veronique D Morinville; Chee Y Ooi; Sarah Jane Schwarzenberg; David M Troendle; Elizabeth Yen; Aliye Uc

doi:10.1097/MPG.0000000000001446

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The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group

Journal article

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The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group

Cheryl E Gariepy, Melvin B Heyman, Mark E Lowe, John F Pohl, Steven L Werlin, Michael Wilschanski, Bradley Barth, Douglas S Fishman, Steven D Freedman, Matthew J Giefer, …

Journal of pediatric gastroenterology and nutrition, Vol.64(1), pp.95-103

01/2017

DOI: 10.1097/MPG.0000000000001446

PMCID: PMC5191966

PMID: 27782962

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Abstract

Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates over the past decade. However, as pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. Objectives: To review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research. Methods: A systematic review of the literature was performed and scored for quality, then consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group. Results: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed. Conclusion: This consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.

autoimmune pancreatitis

PRSS1

pancreatic insufficiency

hereditary pancreatitis

CFTR

Details

Title: Subtitle: The Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group
Creators: Cheryl E Gariepy - Nationwide Children’s Hospital and The Ohio State University, Columbus, OH, USA
Melvin B Heyman - University of California at San Francisco, San Francisco, CA, USA
Mark E Lowe - Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
John F Pohl - University of Utah, Salt Lake City, UT, USA
Steven L Werlin - Medical College of Wisconsin, Milwaukee, WI, USA
Michael Wilschanski - Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Bradley Barth - University of Texas Southwestern Medical School, Dallas, TX, USA
Douglas S Fishman - Baylor College of Medicine, Houston, TX, USA
Steven D Freedman - Harvard Medical School, Boston, MA, USA
Matthew J Giefer - Seattle Children’s Hospital, Seattle, WA, USA
Tanja Gonska - Hospital for Sick Children, Toronto, ON, Canada
Ryan Himes - Baylor College of Medicine, Houston, TX, USA
Sohail Z Husain - Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
Veronique D Morinville - Montreal Children’s Hospital, McGill University, Montreal, QC, Canada
Chee Y Ooi - University of New South Wales and Sydney Children’s Hospital Randwick Sydney, Australia
Sarah Jane Schwarzenberg - University of Minnesota Masonic Children’s Hospital, Minneapolis, Minnesota, USA
David M Troendle - University of Texas Southwestern Medical School, Dallas, TX, USA
Elizabeth Yen - University of California at San Francisco, San Francisco, CA, USA
Aliye Uc - University of Iowa Children’s Hospital, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.64(1), pp.95-103
DOI: 10.1097/MPG.0000000000001446
PMID: 27782962
PMCID: PMC5191966
NLM abbreviation: J Pediatr Gastroenterol Nutr
ISSN: 0277-2116
eISSN: 1536-4801
Language: English
Date published: 01/2017
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984047659602771

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