Journal article
The Challenges and Opportunities in the Development of MicroRNA Therapeutics: A Multidisciplinary Viewpoint
Cells (Basel, Switzerland), Vol.10(11), p.3097
11/01/2021
DOI: 10.3390/cells10113097
PMCID: PMC8619171
PMID: 34831320
Abstract
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size, specific targetability, and critical role in disease pathogenesis. However, < 20 miR targeting molecules have entered clinical trials, and none progressed to phase III. The difficulties in miR target identification, the moderate efficacy of miR inhibitors, cell type-specific delivery, and adverse outcomes have impeded the development of miR therapeutics. These hurdles are rooted in the functional complexity of miR's role in disease and sequence complementarity-dependent/-independent effects in nontarget tissues. The advances in understanding miR's role in disease, the development of efficient miR inhibitors, and innovative delivery approaches have helped resolve some of these hurdles. In this review, we provide a multidisciplinary viewpoint on the challenges and opportunities in the development of miR therapeutics.
Details
- Title: Subtitle
- The Challenges and Opportunities in the Development of MicroRNA Therapeutics: A Multidisciplinary Viewpoint
- Creators
- Mohammad Yahya Momin - Mylan Laboratories Ltd. R&D Centre, Bangalore 560105, Karnataka, India.Ravinder Reddy Gaddam - Roy J. and Lucille A. Carver College of MedicineMadeline Kravitz - University of Saint JosephAnisha Gupta - University of Saint JosephAjit Vikram - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Cells (Basel, Switzerland), Vol.10(11), p.3097
- DOI
- 10.3390/cells10113097
- PMID
- 34831320
- PMCID
- PMC8619171
- NLM abbreviation
- Cells
- ISSN
- 2073-4409
- eISSN
- 2073-4409
- Publisher
- Mdpi
- Number of pages
- 21
- Grant note
- 18CDA34080125; 19POST34380127; 828081 / American Heart Association (AHA); American Heart Association
- Language
- English
- Date published
- 11/01/2021
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984360155702771
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