Journal article
The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24
American journal of ophthalmology, Vol.138(6), pp.936-951
12/2004
DOI: 10.1016/j.ajo.2004.07.006
PMID: 15629284
Abstract
To report rates of death and related outcomes through 10 years after treatment of large choroidal melanoma and to evaluate characteristics of patients and tumors as predictors of relative treatment effectiveness and time to death. Randomized multicenter clinical trial of pre-enucleation radiation vs enucleation alone conducted as part of the Collaborative Ocular Melanoma Study. Eligible patients were free of metastasis and other cancers at enrollment. All patients were followed for 5 years or longer at scheduled examinations and contacts for metastasis, another cancer, or death. Each decedent was classified as having histopathologically confirmed melanoma metastasis, suspected melanoma metastasis without histopathologic confirmation, another cancer but not melanoma metastasis, or no malignancy. Within 10 years after enrollment, 576 of 1,003 patients died. Ten-year all-cause mortality rates were 61% for patients in both treatment arms. Ten-year rates of death with histopathologically confirmed melanoma metastasis were 45% in the pre-enucleation radiation arm and 40% in the enucleation alone arm. Older age and larger maximum basal tumor diameter were the primary predictors of time to death from all causes and death with melanoma metastasis. No differences in unadjusted or adjusted mortality rates were found between treatment arms. Of 448 patients eligible for 10 years of follow-up, 145 patients (32%) were alive and clinically cancer-free 10 years after treatment. Longer follow-up confirmed the earlier report of no survival advantage attributable to pre-enucleation radiation. Mortality rates by baseline characteristics should facilitate counseling of patients who have large choroidal melanoma and no evidence of metastasis or another malignancy at diagnosis.
Details
- Title: Subtitle
- The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24
- Creators
- Barbara S Hawkins - bhawkins@jhmi.eduCollaborative Ocular Melanoma Study Group
- Resource Type
- Journal article
- Publication Details
- American journal of ophthalmology, Vol.138(6), pp.936-951
- Publisher
- United States
- DOI
- 10.1016/j.ajo.2004.07.006
- PMID
- 15629284
- ISSN
- 0002-9394
- eISSN
- 1879-1891
- Grant note
- EY06266 / NEI NIH HHS EY06257 / NEI NIH HHS EY06858 / NEI NIH HHS EY06280 / NEI NIH HHS EY06275 / NEI NIH HHS EY06899 / NEI NIH HHS EY06279 / NEI NIH HHS EY06288 / NEI NIH HHS EY06284 / NEI NIH HHS EY06258 / NEI NIH HHS EY06848 / NEI NIH HHS EY06276 / NEI NIH HHS EY06839 / NEI NIH HHS EY06844 / NEI NIH HHS EY06289 / NEI NIH HHS EY06253 / NEI NIH HHS EY06282 / NEI NIH HHS EY06268 / NEI NIH HHS EY06264 / NEI NIH HHS EY06291 / NEI NIH HHS EY06843 / NEI NIH HHS EY06260 / NEI NIH HHS EY06274 / NEI NIH HHS EY06283 / NEI NIH HHS EY06269 / NEI NIH HHS EY06265 / NEI NIH HHS EY06270 / NEI NIH HHS EY06287 / NEI NIH HHS
- Language
- English
- Date published
- 12/2004
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979901802771
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