The Collaborative Study on the Genetics of Alcoholism: Overview

Arpana Agrawal; Sarah J Brislin; Kathleen K Bucholz; Danielle Dick; Ronald P Hart; Emma C Johnson; Jacquelyn Meyers; Jessica Salvatore; Paul Slesinger; Collaborative Study on the Genetics of Alcoholism (COGA) Collaborators; Y Liu; M H Plawecki; C Kamarajan; A Pandey; L Bierut; J Rice; M Schuckit; D Scott; L Bauer; L Wetherill; X Xuei; D Lai; S O'Connor; G Chan; D B Chorlian; J Zhang; P Barr; S Kinreich; G Pandey; N Mullins; A Anokhin; S Hartz; V McCutcheon; S Saccone; J Moore; F Aliev; Z Pang; S Kuo; H Chin; A Parsian; Laura Almasy; Tatiana Foroud; Alison Goate; Victor Hesselbrock; John Kramer; Samuel Kuperman; Alison K Merikangas; John I Nurnberger; Jay Tischfield; Howard J Edenberg; Bernice Porjesz

doi:10.1111/gbb.12864

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The Collaborative Study on the Genetics of Alcoholism: Overview

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The Collaborative Study on the Genetics of Alcoholism: Overview

Arpana Agrawal, Sarah J Brislin, Kathleen K Bucholz, Danielle Dick, Ronald P Hart, Emma C Johnson, Jacquelyn Meyers, Jessica Salvatore, Paul Slesinger, Collaborative Study on the Genetics of Alcoholism (COGA) Collaborators, …

Genes, brain, and behavior, Vol.22(5), e12864

10/01/2023

DOI: 10.1111/gbb.12864

PMCID: PMC10550790

PMID: 37736010

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Abstract

Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders with etiological origins in the brain and the environment. To outline the causes and consequences of alcohol-related milestones, including AUD, and their related psychiatric comorbidities, the Collaborative Study on the Genetics of Alcoholism (COGA) was launched in 1989 with a gene-brain-behavior framework. COGA is a family based, diverse (~25% self-identified African American, ~52% female) sample, including data on 17,878 individuals, ages 7-97 years, in 2246 families of which a proportion are densely affected for AUD. All participants responded to questionnaires (e.g., personality) and the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) which gathers information on psychiatric diagnoses, conditions and related behaviors (e.g., parental monitoring). In addition, 9871 individuals have brain function data from electroencephalogram (EEG) recordings while 12,009 individuals have been genotyped on genome-wide association study (GWAS) arrays. A series of functional genomics studies examine the specific cellular and molecular mechanisms underlying AUD. This overview provides the framework for the development of COGA as a scientific resource in the past three decades, with individual reviews providing in-depth descriptions of data on and discoveries from behavioral and clinical, brain function, genetic and functional genomics data. The value of COGA also resides in its data sharing policies, its efforts to communicate scientific findings to the broader community via a project website and its potential to nurture early career investigators and to generate independent research that has broadened the impact of gene-brain-behavior research into AUD.

Biological Sciences

Brain

Brain Disorders

Family

Genetics

Genomics

Human Genome

Mental Health

alcohol dependence

Alcohol Use and Health

alcohol use disorder

Alcoholism

AUD

Behavioral and Social Science

Clinical Research

COGA Collaborators

developmental

EEG

ERP

Good Health and Well Being

lifespan

longitudinal

Medical and Health Sciences

Neurology & Neurosurgery

Neurosciences

psychiatric

Psychology and Cognitive Sciences

SSAGA

Substance Misuse

Details

Title: Subtitle: The Collaborative Study on the Genetics of Alcoholism: Overview
Creators: Arpana Agrawal
Sarah J Brislin
Kathleen K Bucholz
Danielle Dick
Ronald P Hart
Emma C Johnson
Jacquelyn Meyers
Jessica Salvatore
Paul Slesinger
Collaborative Study on the Genetics of Alcoholism (COGA) Collaborators
Y Liu
M H Plawecki
C Kamarajan
A Pandey
L Bierut
J Rice
M Schuckit
D Scott
L Bauer
L Wetherill
X Xuei
D Lai
S O'Connor
G Chan
D B Chorlian
J Zhang
P Barr
S Kinreich
G Pandey
N Mullins
A Anokhin
S Hartz
V McCutcheon
S Saccone
J Moore
F Aliev
Z Pang
S Kuo
H Chin
A Parsian
Laura Almasy
Tatiana Foroud
Alison Goate
Victor Hesselbrock
John Kramer
Samuel Kuperman
Alison K Merikangas
John I Nurnberger
Jay Tischfield
Howard J Edenberg
Bernice Porjesz
Resource Type: Journal article
Publication Details: Genes, brain, and behavior, Vol.22(5), e12864
DOI: 10.1111/gbb.12864
PMID: 37736010
PMCID: PMC10550790
NLM abbreviation: Genes Brain Behav
ISSN: 1601-1848
eISSN: 1601-183X
Publisher: Wiley
Grant note: DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: U10AA008401; DOI: 10.13039/100000026, name: National Institute on Drug Abuse
Language: English
Date published: 10/01/2023
Academic Unit: Psychiatry
Record Identifier: 9984502957902771

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