Journal article
The Combination of Low Cytoplasmic and High Nuclear Expression of p27 Predicts a Better Prognosis in High-grade Astrocytoma
Anticancer research, Vol.29(2), pp.597-603
02/01/2009
PMID: 19331209
Abstract
Background: The function of the cyclin-dependent kinase (cdk) inhibitor p27 is regulated by translocation between the nucleus (activate) and the cytosol (inactivate). No previous reports have examined the subcellular localization of p27 in glioma which was evaluated here regarding the prognosis in high-grade astrocytomas. Patients and Methods: The pattern of subcellular localization of p27 expression was examined immunohistochemically in 49 patients with high-grade astrocytoma who were over 20 years of age. The relationship between p27 localization and the prognosis was statistically examined. Results: Kaplan-Meier survival analysis showed that cytoplasmic p27 expression was statistically associated with a worse prognosis (p=0.0203), while nuclear p27 expression showed some tendency towords a better prognosis (p=0.1180). Cox multiple regression analysis showed the combination of high nuclear and low cytoplasmic p27 expression associated with a significantly better prognosis in high-grade astrocytoma. Conclusion: A combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytomas and thus the subcellular localization of p27 expression is useful for predicting the prognosis for these patients.
Details
- Title: Subtitle
- The Combination of Low Cytoplasmic and High Nuclear Expression of p27 Predicts a Better Prognosis in High-grade Astrocytoma
- Creators
- Toshikazu Hidaka - Hiroshima UniversitySeiji Hama - Hiroshima UniversityPrabin Shrestha - Hiroshima UniversityTaiichi Saito - Hiroshima UniversityYoshinori Kajiwara - Hiroshima UniversityFumiyuki Yamasaki - Hiroshima UniversityKazuhiko Sugiyama - Hiroshima UniversityKaoru Kurisu - Hiroshima University
- Resource Type
- Journal article
- Publication Details
- Anticancer research, Vol.29(2), pp.597-603
- Publisher
- Int Inst Anticancer Research
- PMID
- 19331209
- ISSN
- 0250-7005
- eISSN
- 1791-7530
- Number of pages
- 7
- Grant note
- Japanese Ministry of Education, Culture, Sports, Science and Technology; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- Language
- English
- Date published
- 02/01/2009
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984695683202771
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