Journal article
The Concept of Osseointegration and Bone Matrix Expression
Critical reviews in oral biology and medicine, Vol.2(1), pp.83-101
01/1991
DOI: 10.1177/10454411910020010601
PMID: 1912145
Abstract
Osseointegration has been defined as the direct structural and functional connection between ordered, living bone and the surface of a load-carrying implant. To date, this concept has been described by descriptive histological and ultrastructural criteria but not by biochemical means. This review evaluates the basic science work performed on this concept and then applies the concept to the principle of osseous healing. Specific studies are cited where alterations in the healing response are due to clinical management of implant placement and how studies of surface properties may lead to further insights on implant design and prognosis. In addition, a review of bone expression as a function of in vitro stress applications is given. This is followed by an indepth review of the collagens and noncollagenous proteins, described to date, within isolated bone matrix. It is this collagenous matrix (especially type I) that is described as being close to and oriented with a glycoprotein component next to the implant surface. In turn, the large family of noncollagenous proteins are important in mediating bone proliferation, matrix accumulation, orientation, mineralization, and turnover. This section is followed by a discussion of specific growth factors as they may relate to osseous healing around an implant.
Details
- Title: Subtitle
- The Concept of Osseointegration and Bone Matrix Expression
- Creators
- Clark M Stanford - Dows Institute for Dental Research, University of Iowa, College of Dentistry, lowa City, IA 52242John C Keller - Dows Institute for Dental Research, University of Iowa, College of Dentistry, lowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Critical reviews in oral biology and medicine, Vol.2(1), pp.83-101
- DOI
- 10.1177/10454411910020010601
- PMID
- 1912145
- NLM abbreviation
- Crit Rev Oral Biol Med
- ISSN
- 1045-4411
- eISSN
- 1544-1113
- Language
- English
- Date published
- 01/1991
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Prosthodontics; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984066098702771
Metrics
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