Journal article
The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British journal of pharmacology, Vol.182 (Suppl 1), pp.S1-S23
12/2025
DOI: 10.1111/bph.70229
PMID: 41461576
Abstract
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the www.guidetopharmacology.org website, the printed guide serves as a permanent, citable, point-in-time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70229. The Concise Guides provide expert-curated recommendations of 'Gold Standard' selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025/26 edition of the Concise Guide is based on material current as of mid-2025, and supersedes all previous editions, including the 2023/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable. In addition to this general overview, which includes a section on 'Other protein targets' that fall outside of the main classifications, the Concise Guide focuses on six key areas: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.
Details
- Title: Subtitle
- The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
- Creators
- Stephen P H Alexander - University of NottinghamAlasdair J Gibb - University College LondonEamonn Kelly - University of BristolAlistair A Mathie - University of WestminsterChloe J Peach - University of NottinghamEmma L Veale - Medway School of PharmacyJohn A Cidlowski - National Institute of Environmental Health SciencesAnthony P Davenport - University of CambridgeDoriano Fabbro - PIQUR TherapeuticsMichael Spedding - Clinical SolutionsJörg Striessnig - Universität InnsbruckJane F Armstrong - University of EdinburghO Peter Buneman - University of EdinburghElena Faccenda - University of EdinburghSimon D Harding - University of EdinburghChristopher Southan - University of EdinburghJamie A Davies - University of EdinburghKatelin E Ahlers-Dannen - University of IowaMohammed Alqinyah - University of GeorgiaThiruma V Arumugam - National University of SingaporeChristopher Bodle - University of IowaJosephine Buo Dagner - University of GeorgiaBandana Chakravarti - University of IowaShreoshi P Choudhuri - The University of Texas Southwestern Medical CenterKirk M Druey - National Institutes of HealthRory A Fisher - University of IowaKyle J Gerber - TetracoreJohn R Hepler - Emory UniversityShelley B Hooks - University of GeorgiaHavish S Kantheti - The University of Texas Southwestern Medical CenterBehirda Karaj - Michigan State UniversitySomayeh Layeghi-Ghalehsoukhteh - Shiraz UniversityJae-Kyung Lee - University of GeorgiaZili Luo - University of IowaKirill Martemyanov - Scripps Research InstituteLuke D Mascarenhas - The University of Texas Southwestern Medical CenterHarrison McNabb - Purdue University West LafayetteCarolina Montañez-Miranda - Emory UniversityDavid L Roman - University of IowaOsita Ogujiofor - The University of Texas Southwestern Medical CenterHoa Phan - Michigan State UniversityVincent Shaw - Michigan State UniversityBenita Sjogren - Purdue University West LafayetteChristopher Sobey - La Trobe UniversityMackenzie M Spicer - University of IowaKatherine E Squires - Emory UniversityLaurie Sutton - Jupiter Medical CenterMenbere Wendimu - University of GeorgiaThomas Wilkie - The University of Texas Southwestern Medical CenterKeqiang Xie - Scripps Research InstituteQian Zhang - Purdue University West LafayetteYalda Zolghadri - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- British journal of pharmacology, Vol.182 (Suppl 1), pp.S1-S23
- DOI
- 10.1111/bph.70229
- PMID
- 41461576
- NLM abbreviation
- Br J Pharmacol
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- Publisher
- WILEY; HOBOKEN
- Grant note
- International Union of Basic and Clinical PharmacologyBritish Pharmacological SocietySociety Italiana di FarmacologiaDeutsche Gesellschaft fuer Experimentelle und Klinische Pharmakologie und ToxikologieIUPHARWellcome Trust: 099156/Z/12/Z
We are very grateful to the International Union of Basic and Clinical Pharmacology, the British Pharmacological Society, the Society Italiana di Farmacologia and the Deutsche Gesellschaft fuer Experimentelle und Klinische Pharmakologie und Toxikologie for financial support for the IUPHAR/BPS Guide to Pharmacology, and to the University of Edinburgh, who host the https://www.guidetopharmaco logy.org website. We gratefully acknowledge previous funding from IUPHAR and the Wellcome Trust (099156/Z/12/Z) who supported the initiation and expansion of the database. A major influence on the development of the database was Tony Harmar (1951- 2014), who worked with a passion to establish the database curators to ensure a suitably validated dataset. We are also tremendously grateful to the long list of collaborators from NC-IUPHAR subcommittees and beyond, who have assisted in the construction of the Concise Guide to Pharmacology 2025/26 and the online database https://www.guidetopharmacology.org.
- Language
- English
- Date published
- 12/2025
- Academic Unit
- Neurology; Pharmacy; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Neuroscience and Pharmacology; Medicinal and Natural Products Chemistry; Internal Medicine
- Record Identifier
- 9985113255902771
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