Journal article
The Contribution of Network Organization and Integration to the Development of Cognitive Control
PLoS biology, Vol.13(12), pp.e1002328-e1002328
12/2015
DOI: 10.1371/journal.pbio.1002328
PMCID: PMC4694653
PMID: 26713863
Abstract
Cognitive control, which continues to mature throughout adolescence, is supported by the ability for well-defined organized brain networks to flexibly integrate information. However, the development of intrinsic brain network organization and its relationship to observed improvements in cognitive control are not well understood. In the present study, we used resting state functional magnetic resonance imaging (RS-fMRI), graph theory, the antisaccade task, and rigorous head motion control to characterize and relate developmental changes in network organization, connectivity strength, and integration to inhibitory control development. Subjects were 192 10-26-y-olds who were imaged during 5 min of rest. In contrast to initial studies, our results indicate that network organization is stable throughout adolescence. However, cross-network integration, predominantly of the cingulo-opercular/salience network, increased with age. Importantly, this increased integration of the cingulo-opercular/salience network significantly moderated the robust effect of age on the latency to initiate a correct inhibitory control response. These results provide compelling evidence that the transition to adult-level inhibitory control is dependent upon the refinement and strengthening of integration between specialized networks. Our findings support a novel, two-stage model of neural development, in which networks stabilize prior to adolescence and subsequently increase their integration to support the cross-domain incorporation of information processing critical for mature cognitive control.
Details
- Title: Subtitle
- The Contribution of Network Organization and Integration to the Development of Cognitive Control
- Creators
- Scott Marek - Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of AmericaKai Hwang - Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, United States of AmericaWilliam Foran - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of AmericaMichael N Hallquist - Department of Psychology, The Pennsylvania State University, State College, Pennsylvania, United States of AmericaBeatriz Luna - Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
- Resource Type
- Journal article
- Publication Details
- PLoS biology, Vol.13(12), pp.e1002328-e1002328
- DOI
- 10.1371/journal.pbio.1002328
- PMID
- 26713863
- PMCID
- PMC4694653
- NLM abbreviation
- PLoS Biol
- ISSN
- 1544-9173
- eISSN
- 1545-7885
- Publisher
- United States
- Grant note
- K01 MH097091 / NIMH NIH HHS R01 MH080243 / NIMH NIH HHS MH080243 / NIMH NIH HHS
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002489102771
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