Journal article
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
Neuron (Cambridge, Mass.), Vol.32(6), pp.1071-1083
2001
DOI: 10.1016/S0896-6273(01)00547-5
PMID: 11754838
Abstract
Cation channels in the DEG/ENaC family are proposed to detect cutaneous stimuli in mammals. We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception. Disrupting the mouse DRASIC gene altered sensory transduction in specific and distinct ways. Loss of DRASIC increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid- and noxious heat-sensitive nociceptors. The data suggest that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons. Moreover, in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation.
Details
- Title: Subtitle
- The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
- Creators
- Margaret P Price - Howard Hughes Medical Institute, Iowa City, IA 52242 USASabrina L McIlwrath - Growth Factors and Regeneration Group, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin-Buch, GermanyJinghui Xie - Howard Hughes Medical Institute, Iowa City, IA 52242 USAChun Cheng - Howard Hughes Medical Institute, Iowa City, IA 52242 USAJing Qiao - Howard Hughes Medical Institute, Iowa City, IA 52242 USADeirdre E Tarr - Howard Hughes Medical Institute, Iowa City, IA 52242 USAKathleen A Sluka - Physical Therapy Graduate Program, Iowa City, IA 52242 USATimothy J Brennan - Department of Anesthesia, Iowa City, IA 52242 USAGary R Lewin - Growth Factors and Regeneration Group, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin-Buch, GermanyMichael J Welsh - Howard Hughes Medical Institute, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.32(6), pp.1071-1083
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0896-6273(01)00547-5
- PMID
- 11754838
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 2001
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Iowa Neuroscience Institute; Nursing; Anesthesia; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020714802771
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