Journal article
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Alzheimer's & dementia, Vol.11(2), pp.111-125
02/2015
DOI: 10.1016/j.jalz.2014.05.1756
PMCID: PMC4422168
PMID: 25267715
Abstract
An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.
Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.
The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).
The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
Details
- Title: Subtitle
- The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
- Creators
- Giovanni B. Frisoni - University of GenevaClifford R. Jack - Mayo ClinicMartina Bocchetta - Centro San Giovanni di Dio FatebenefratelliCorinna Bauer - Boston UniversityKristian S. Frederiksen - RigshospitaletYawu Liu - University of Eastern FinlandGregory Preboske - Mayo ClinicTim Swihart - Oregon Health & Science UniversityMelanie Blair - National Hospital for Neurology and NeurosurgeryEnrica Cavedo - Centro San Giovanni di Dio FatebenefratelliMichel J. Grothe - German Center for Neurodegenerative DiseasesMariangela Lanfredi - Centro San Giovanni di Dio FatebenefratelliOliver Martinez - University of California, DavisMasami Nishikawa - Kawamura Gakuen Women's UniversityMarileen Portegies - University Medical Center UtrechtTravis Stoub - Rush UniversityChadwich Ward - Mayo ClinicLiana G. Apostolova - Alzheimer’s Disease Neuroimaging InitiativeRossana Ganzola - Institut Universitaire en Santé Mentale de QuébecDominik Wolf - Klinik für Psychiatrie und Psychotherapie, Johannes Gutenberg-Universität Mainz, Mainz, GermanyFrederik Barkhof - Vrije Universiteit AmsterdamGeorge Bartzokis - David Geffen School of Medicine at UCLACharles DeCarli - University of California, DavisJohn G. Csernansky - Northwestern UniversityLeyla deToledo-Morrell - Rush UniversityMirjam I. Geerlings - University Medical Center UtrechtJeffrey Kaye - Oregon Health & Science UniversityRonald J. Killiany - Boston UniversityStephane Lehéricy - Pitié-Salpêtrière HospitalHiroshi Matsuda - Kawamura Gakuen Women's UniversityJohn O'Brien - Newcastle UniversityLisa C. Silbert - Oregon Health & Science UniversityPhilip Scheltens - Amsterdam NeuroscienceHilkka Soininen - University of Eastern FinlandStefan Teipel - German Center for Neurodegenerative DiseasesGunhild Waldemar - RigshospitaletAndreas Fellgiebel - Johannes Gutenberg University MainzJosephine Barnes - National Hospital for Neurology and NeurosurgeryMichael Firbank - Newcastle Hospitals - Campus for Ageing and VitalityLotte Gerritsen - University Medical Center UtrechtWouter Henneman - Department of Radiology and Nuclear Medicine, Image Analysis Center, VU University Medical Center, Amsterdam, The NetherlandsNikolai Malykhin - University of AlbertaJens C. Pruessner - McGill UniversityLei Wang - Northwestern UniversityCraig Watson - University of California, DavisHenrike Wolf - University of ZurichMony deLeon - New York University School of Medicine, Center for Brain Health, New York, NY, USAJohannes Pantel - Goethe University FrankfurtClarissa Ferrari - Centro San Giovanni di Dio FatebenefratelliPaolo Bosco - Centro San Giovanni di Dio FatebenefratelliPatrizio Pasqualetti - IRCCS Ospedale San RaffaeleSimon Duchesne - Institut Universitaire en Santé Mentale de QuébecHenri Duvernoy - Observatoire des Sciences de l’Univers Terre Homme Environnement Temps AstronomieMarina Boccardi - Centro San Giovanni di Dio FatebenefratelliMarilyn S. Albert - Mayo ClinicDavid Bennet - Centro San Giovanni di Dio FatebenefratelliRichard Camicioli - University of BresciaD. Louis Collins - Centro San Giovanni di Dio FatebenefratelliBruno Dubois - Centro San Giovanni di Dio FatebenefratelliHarald Hampel - Centro San Giovanni di Dio FatebenefratelliTom denHeijer - University of BresciaChristofer Hock - Centro San Giovanni di Dio FatebenefratelliWilliam Jagust - Boston UniversityLeonore Launer - Centro San Giovanni di Dio FatebenefratelliJerome J. Maller - Mayo ClinicSusan Mueller - Centro San Giovanni di Dio FatebenefratelliPerminder Sachdev - University of BresciaAndy Simmons - Centro San Giovanni di Dio FatebenefratelliPaul M. Thompson - University of BresciaPeter-Jelle VisserLars-Olof WahlundMichael W. Weiner - Mayo ClinicBengt Winblad - Centro San Giovanni di Dio FatebenefratelliEADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.11(2), pp.111-125
- DOI
- 10.1016/j.jalz.2014.05.1756
- PMID
- 25267715
- PMCID
- PMC4422168
- NLM abbreviation
- Alzheimers Dement
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Publisher
- Elsevier Inc
- Number of pages
- 15
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Radiology
- Record Identifier
- 9984848422102771
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