Journal article
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Brain Imaging and Behavior, Vol.8(2), pp.153-182
01/08/2014
DOI: 10.1007/s11682-013-9269-5
PMCID: PMC4008818
PMID: 24399358
Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
Details
- Title: Subtitle
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
- Creators
- Paul M ThompsonJason L SteinSarah E MedlandDerrek P HibarAlejandro Arias VasquezMiguel E RenteriaRoberto ToroNeda JahanshadGunter SchumannBarbara FrankeMargaret J WrightNicholas G MartinIngrid AgartzMartin AldaSaud AlhusainiLaura AlmasyJorge AlmeidaKathryn AlpertNancy C AndreasenOle A AndreassenLiana G ApostolovaKatja AppelNicola J ArmstrongBenjamin AribisalaMark E BastinMichael BauerCarrie E BeardenØrjan BergmannElisabeth B BinderJohn BlangeroHenry J BockholtErlend BøenCatherine BoisDorret I BoomsmaTom BoothIan J BowmanJanita BraltenRachel M BrouwerHan G BrunnerDavid G BrohawnRandy L BucknerJan BuitelaarKazima BulayevaJuan R BustilloVince D CalhounDara M CannonRita M CantorMelanie A CarlessXavier CaserasGianpiero L CavalleriM. Mallar ChakravartyKiki D ChangChristopher R. K ChingAndrea ChristoforouSven CichonVincent P ClarkPatricia ConrodGiovanni CoppolaBenedicto Crespo-FacorroJoanne E CurranMichael CzischIan J DearyEco J. C de GeusAnouk den BraberGiuseppe DelvecchioChantal DepondtLieuwe de HaanGreig I de ZubicarayDanai DimaRali DimitrovaSrdjan DjurovicHongwei DongGary DonohoeRavindranath DuggiralaThomas D DyerStefan EhrlichCarl Johan EkmanTorbjørn ElvsåshagenLouise EmsellSusanne ErkThomas EspesethJesen FagernessScott FearsIryna FedkoGuillén FernándezSimon E FisherTatiana ForoudPeter T FoxClyde FrancksSophia FrangouEva Maria FreyThomas FrodlVincent FrouinHugh GaravanSudheer GiddaluruDavid C GlahnBeata GodlewskaRita Z GoldsteinRandy L GollubHans J GrabeOliver GrimmOliver GruberTulio GuadalupeRaquel E GurRuben C GurHarald H. H GöringSaskia HagenaarsTomas HajekGeoffrey B HallJeremy HallJohn HardyCatharina A HartmanJohanna HassSean N HattonUnn K HaukvikKatrin HegenscheidAndreas HeinzIan B HickieBeng-Choon HoDavid HoehnPieter J HoekstraMarisa HollinsheadAvram J HolmesGeorg HomuthMartine HoogmanL. Elliot HongNorbert HostenJouke-Jan HottengaHilleke E Hulshoff PolKristy S HwangClifford R JackMark JenkinsonCaroline JohnstonErik G JönssonRené S KahnDalia KasperaviciuteSinead KellySungeun KimPeter KochunovLaura KoendersBernd KrämerJohn B. J KwokJim LagopoulosGonzalo LajeMikael LandenBennett A LandmanJohn LaurielloStephen M LawriePhil H LeeStephanie Le HellardHerve LemaîtreCassandra D LeonardoChiang-shan LiBenny LibergDavid C LiewaldXinmin LiuLorna M LopezEva LothAnbarasu LourdusamyMichelle LucianoFabio MacciardiMarise W. J MachielsenGlenda M MacQueenUlrik F MaltRené MandlDara S ManoachJean-Luc MartinotMar MatarinKaren A MatherManuel MattheisenMorten MattingsdalAndreas Meyer-LindenbergColm McDonaldAndrew M McIntoshFrancis J McMahonKatie L McMahonEva MeisenzahlIngrid MelleYuri MilaneschiSebastian MohnkeGrant W MontgomeryDerek W MorrisEric K MosesBryon A MuellerSusana Muñoz ManiegaThomas W MühleisenBertram Müller-MyhsokBenson MwangiMatthias NauckKwangsik NhoThomas E NicholsLars-Göran NilssonAllison C NugentLars NybergRene L OlveraJaap OosterlaanRoel A OphoffMassimo PandolfoMelina Papalampropoulou-TsiridouTomas PausMartina PapmeyerZdenka PausovaGodfrey D PearlsonBrenda W PenninxCharles P PetersonAndrea PfennigMary PhillipsG. Bruce PikeJean-Baptiste PolineSteven G PotkinBenno PützAdaikalavan RamasamyJerod RasmussenMarcella RietschelMark RijpkemaShannon L RisacherJoshua L RoffmanRoberto Roiz-SantiañezNina Romanczuk-SeiferthEmma J RoseNatalie A RoyleDan RujescuMina RytenPerminder S SachdevAlireza SalamiTheodore D SatterthwaiteJonathan SavitzAndrew J SaykinCathy ScanlonLianne SchmaalHugo G SchnackAndrew J SchorkS. Charles SchulzRemmelt SchürLarry SeidmanLi ShenJody M ShoemakerAndrew SimmonsSanjay M SisodiyaColin SmithJordan W SmollerJair C SoaresScott R SponheimEmma SprootenJohn M StarrVidar M SteenStephen StrakowskiLachlan StrikeJessika SussmannPhilipp G SämannAlexander TeumerArthur W TogaDiana Tordesillas-GutierrezDaniah TrabzuniSarah TrostJessica TurnerMartijn Van den HeuvelNic J van der WeeKristel van EijkTheo G. M van ErpNeeltje E. M van HarenDennis van ‘t EntMarie-Jose van TolMaria C Valdés HernándezDick J VeltmanAmelia VersaceHenry VölzkeRobert WalkerHenrik WalterLei WangJoanna M WardlawMichael E WealeMichael W WeinerWei WenLars T WestlyeHeather C WhalleyChristopher D WhelanTonya WhiteAnderson M WinklerKatharina WittfeldGirma WoldehawariatChristiane WolfDavid ZillesMarcel P ZwiersAnbupalam ThalamuthuPeter R SchofieldNelson B FreimerNatalia S LawrenceWayne Drevets
- Resource Type
- Journal article
- Publication Details
- Brain Imaging and Behavior, Vol.8(2), pp.153-182
- Publisher
- Springer Nature
- DOI
- 10.1007/s11682-013-9269-5
- PMID
- 24399358
- PMCID
- PMC4008818
- ISSN
- 1931-7557
- eISSN
- 1931-7565
- Language
- English
- Date published
- 01/08/2014
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984068340102771
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