The Editors' Choice

Cezmi A Akdis; Zuhair K Ballas

doi:10.1016/j.jaci.2016.05.012

Back

Journal article

Open access

Peer reviewed

The Editors' Choice

Cezmi A Akdis and Zuhair K Ballas

Journal of allergy and clinical immunology, Vol.138(1), p.59

07/01/2016

DOI: 10.1016/j.jaci.2016.05.012

PMID: 27373327

Files and links (1)

url

https://doi.org/10.1016/j.jaci.2016.05.012View

Published (Version of record) Open Access

Abstract

First come, first served Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic inflammatory disorder. When the researchers weakened DNA DSB repair in mice and in human cell lines by using the DNA repair inhibitor NU7441, they observed more DNA DSBs in bronchial epithelial cells in vivo, enhanced HDM-induced cell death, and augmented proinflammatory cytokine (IL-4, IL-5, IL-13, and IL-33) production in vitro.

Cytokines

Lymphocytes

Inflammation

Mutation

DNA repair

Lymphoma

Allergies

Inflammatory diseases

Deoxyribonucleic acid--DNA

Asthma

Details

Title: Subtitle: The Editors' Choice
Creators: Cezmi A Akdis
Zuhair K Ballas
Resource Type: Journal article
Publication Details: Journal of allergy and clinical immunology, Vol.138(1), p.59
DOI: 10.1016/j.jaci.2016.05.012
PMID: 27373327
NLM abbreviation: J Allergy Clin Immunol
ISSN: 0091-6749
eISSN: 1097-6825
Publisher: Elsevier Limited
Language: English
Date published: 07/01/2016
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094552202771

Metrics

12 Record Views