Journal article
The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis
The New England Journal of Medicine, Vol.329(24), pp.1764-1769
12/09/1993
DOI: 10.1056/NEJM199312093292403
PMID: 8232485
Abstract
Optic neuritis is frequently the first manifestation of multiple sclerosis 1 . Even when optic neuritis occurs without other clinical signs of multiple sclerosis (“isolated optic neuritis”), magnetic resonance imaging (MRI) of the brain often demonstrates signal abnormalities of white matter, 2 – 5 and analysis of cerebrospinal fluid often shows oligoclonal bands 6 – 8 . Within 2 years of an attack of optic neuritis, the risk of multiple sclerosis is approximately 20 percent, 8 – 12 and within 15 years it is in the range of 45 to 80 percent 8 – 11 . The Optic Neuritis Treatment Trial, a multicenter, randomized clinical trial of corticosteroid treatment . . .
Details
- Title: Subtitle
- The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis
- Creators
- Roy W BeckPatricia A ClearyJonathan D TrobeDavid I KaufmanMark J KupersmithDonald W PatyC Hendricks Brown
- Contributors
- Optic Neuritis Study Group (Author)
- Resource Type
- Journal article
- Publication Details
- The New England Journal of Medicine, Vol.329(24), pp.1764-1769
- DOI
- 10.1056/NEJM199312093292403
- PMID
- 8232485
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 12/09/1993
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980085902771
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