Journal article
The Effect of Depression, Generalized Anxiety, and Selective Serotonin Reuptake Inhibitors on Change in Bone Metabolism in Adolescents and Emerging Adults
Journal of bone and mineral research, Vol.32(12), pp.2367-2374
12/01/2017
DOI: 10.1002/jbmr.3238
PMCID: PMC5732069
PMID: 28815738
Abstract
The purpose of this study was to prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Every 4 months, trabecular and cortical volumetric bone mineral density (vBMD) at the radius and markers of bone metabolism were evaluated. Every 8 months, total body less head areal bone mineral content and lumbar spine (LS) areal BMD (aBMD) were determined. Linear mixed-effects regression analysis examined associations between bone measures on the one hand and MDD, GAD, and SSRI indices on the other. A total of 264 participants were followed for 1.51 +/- 0.76 years. After adjusting for age, sex, vitamin D concentration, physical activity, lean mass or grip strength, and time in the study, MDD severity was associated with increasing LS aBMD. Similarly, SSRI use was associated with increasing LS aBMD and bone formation in female participants. In contrast, SSRI use was associated with decreasing LS aBMD in males. After accounting for depression, GAD was independently, albeit weakly, associated with increased bone mineralization. In older adolescents and emerging adults, MDD and GAD are associated with increasing bone mass, particularly in the lumbar spine and in females, whereas SSRIs are associated with increasing bone mass in females but decreasing bone mass in males. (c) 2017 American Society for Bone and Mineral Research.
Details
- Title: Subtitle
- The Effect of Depression, Generalized Anxiety, and Selective Serotonin Reuptake Inhibitors on Change in Bone Metabolism in Adolescents and Emerging Adults
- Creators
- Chadi A. Calarge - Baylor College of MedicineJames A. Mills - Univ Iowa, Iowa City, IA USAKathleen F. Janz - University of IowaTrudy L. Burns - University of IowaJanet A. Schlechte - University of IowaWilliam H. Coryell - University of IowaBabette S. Zemel - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Journal of bone and mineral research, Vol.32(12), pp.2367-2374
- Publisher
- Wiley
- DOI
- 10.1002/jbmr.3238
- PMID
- 28815738
- PMCID
- PMC5732069
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- Number of pages
- 8
- Grant note
- R01MH090072 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) UL1TR000442 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) 2UL1TR000442-06 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Language
- English
- Date published
- 12/01/2017
- Academic Unit
- Psychiatry; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984364411902771
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