The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

Norman L Foster; Abraham F. L VanDerSpek; Michael S Aldrich; Stanley Berent; Richard H Hichwa; J. Chris Sackellares; Sid Gilman; Bernard W Agranoff

doi:10.1038/jcbfm.1987.84

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The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

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The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

Norman L Foster, Abraham F. L VanDerSpek, Michael S Aldrich, Stanley Berent, Richard H Hichwa, J. Chris Sackellares, Sid Gilman and Bernard W Agranoff

Journal of cerebral blood flow and metabolism, Vol.7(4), pp.415-420

06/29/2016

DOI: 10.1038/jcbfm.1987.84

PMID: 3497161

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Abstract

The effect of sedation induced by intravenous diazepam on cerebral glucose metabolic activity was examined with [18F]2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) in five patients with probable Alzheimer's disease. Each subject was studied on 2 separate days: on one occasion at rest with eyes patched and ears open, and on the second when sedated with intravenous diazepam titrated to maintain stage II sleep by clinical and EEG criteria. Similar patterns of glucose uptake were observed in both the presence and the absence of sedation, but overall glucose utilization was depressed an average of 20% and was closely correlated with the amount of diazepam administered prior to the injection of FDG. The predominant temporoparietal hypometabolism and relative sparing of frontal metabolism observed in this disease are therefore not explained by differences in anxiety or activity level in this patient group. Utilization of diazepam sedation for PET study appears to be safe and may permit the study of patients otherwise unable to cooperate with FDG-PET procedures.

Details

Title: Subtitle: The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography
Creators: Norman L Foster
Abraham F. L VanDerSpek - Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, U.S.A
Michael S Aldrich
Stanley Berent - Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A
Richard H Hichwa - Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A
J. Chris Sackellares
Sid Gilman
Bernard W Agranoff - Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A
Resource Type: Journal article
Publication Details: Journal of cerebral blood flow and metabolism, Vol.7(4), pp.415-420
DOI: 10.1038/jcbfm.1987.84
PMID: 3497161
ISSN: 0271-678X
eISSN: 1559-7016
Language: English
Date published: 06/29/2016
Academic Unit: Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984213446002771

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