The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G Raimann; Christopher T Chan; John T Daugirdas; Tom Depner; Frank A Gotch; Tom Greene; George A Kaysen; Alan S Kliger; Peter Kotanko; Brett Larive; Robert Lindsay; Michael V Rocco; Glenn M Chertow; Nathan W Levin; Frequent Hemodialysis Network FHN

doi:10.1159/000441966

Back

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Journal article

Open access

Peer reviewed

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

Jochen G Raimann, Christopher T Chan, John T Daugirdas, Tom Depner, Frank A Gotch, Tom Greene, George A Kaysen, Alan S Kliger, Peter Kotanko, Brett Larive, …

Blood purification, Vol.41(4), pp.277-286

04/2016

DOI: 10.1159/000441966

PMID: 26795100

Files and links (1)

url

https://doi.org/10.1159/000441966View

Published (Version of record) Open Access

Abstract

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

Original Paper

Details

Title: Subtitle: The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials
Creators: Jochen G Raimann
Christopher T Chan
John T Daugirdas
Tom Depner
Frank A Gotch
Tom Greene
George A Kaysen
Alan S Kliger
Peter Kotanko
Brett Larive
Robert Lindsay
Michael V Rocco
Glenn M Chertow
Nathan W Levin
Frequent Hemodialysis Network FHN
Contributors: D Somers (Contributor) - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: Blood purification, Vol.41(4), pp.277-286
DOI: 10.1159/000441966
PMID: 26795100
NLM abbreviation: Blood Purif
ISSN: 0253-5068
eISSN: 1421-9735
Number of pages: 10
Language: English
Date published: 04/2016
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094760202771

Metrics

26 Record Views

34 Times Cited - Web of Science