Journal article
The Effect of Psychostimulants on Skeletal Health in Boys Co-Treated with Risperidone
The Journal of pediatrics, Vol.166(6), pp.1449-1454.e1
06/01/2015
DOI: 10.1016/j.jpeds.2015.03.005
PMCID: PMC4446198
PMID: 25863660
Abstract
Objectives To examine the skeletal effects of chronic psychostimulant treatment in children and adolescents.
Study design Medically healthy 5- to 17-year-old males from 4 different clinic-based studies were combined for this analysis. They were divided by psychostimulant use into 3 groups: none to negligible, intermittent, and continuous use. Most (95%) had also received risperidone for 6 months or more. Treatment history was extracted from medical and pharmacy records. Anthropometric and bone measurements, using dual-energy x-ray absorptiometry and peripheral quantitative computed tomography, were obtained at each research visit. Multivariable linear regression analysis models examined whether age-sex-specific height Z-score and skeletal outcomes differed among the 3 psychostimulant-use groups.
Results The sample consisted of 194 males with a mean age of 11.7 +/- 2.8 years at study entry. The majority had an externalizing disorder. There was no significant difference across the 3 treatment groups in height Z-score or in skeletal outcomes at the radius, lumbar spine, or whole body. One hundred forty-four boys had valid follow-up skeletal data 1.4 +/- 0.7 years after study entry. Again, neither height Z-score nor the skeletal outcomes were different among those who remained on psychostimulants between the 2 visits, started psychostimulants anew, or had not taken psychostimulants.
Conclusions Following chronic treatment, psychostimulants did not appear to significantly affect bone mass accrual in children and adolescents taking risperidone. There was a small, but statistically not significant, negative impact on longitudinal growth.
Details
- Title: Subtitle
- The Effect of Psychostimulants on Skeletal Health in Boys Co-Treated with Risperidone
- Creators
- Chadi A. Calarge - Baylor College of MedicineJanet A. Schlechte - University of IowaTrudy L. Burns - University of IowaBabette S. Zemel - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.166(6), pp.1449-1454.e1
- DOI
- 10.1016/j.jpeds.2015.03.005
- PMID
- 25863660
- PMCID
- PMC4446198
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R21MH080968; K23MH085005 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Fraternal Order of Eagle Diabetes Research Center (pilot grant) UL1RR024979 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) RR024979; R21MH080968; K23MH085005 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 06/01/2015
- Academic Unit
- Psychiatry; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984363594302771
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