Journal article
The Effect of Receiving Treatment Within a Clinical Trial Setting on Survival and Quality of Care Perception in Advanced Stage Non-Small Cell Lung Cancer
American journal of clinical oncology, Vol.39(2), pp.126-131
04/2016
DOI: 10.1097/COC.0000000000000029
PMCID: PMC4411190
PMID: 24632817
Abstract
Treatment outcomes of advanced stage (IIIB and IV) non-small cell lung cancer (NSCLC) are poor. In this study, we explore the survival outcomes and the perception of the quality of care delivered in stage IIIB and IV NSCLC patients treated within versus outside a clinical trial.
Data were obtained from the Cancer Care Outcomes Research and Surveillance Consortium (CanCORS). Baseline characteristics according to clinical trial participation were determined. The association between clinical trial enrollment and survival was assessed using a Cox proportional hazard model after adjusting for age, income, primary data collection and research site, comorbidities, self-reported performance status, presence of brain metastasis, stage IIIB versus IV, and cancer histology.
Of 815 stage IIIB and IV NSCLC patients, 56 (7%) were enrolled in clinical trials. Median survival for the patients treated within versus outside a clinical trial was 20.5 versus 16.7 months, respectively (P=0.21). Using a multivariate survival model, clinical trial enrollment did not correlate with longer survival (P=0.81). Comparing patients according to clinical trial enrollment, patients treated within a clinical trial setting perceived a better overall quality of care (P<0.01).
Management of stage IIIB and IV NSCLC patients within a clinical trial setting conveyed a perception of superior care that did not translate into survival benefit. These findings suggest that providing cancer care within a clinical trial should not imply a survival benefit when counseling stage IIIB and IV NSCLC patients about entering clinical trials.
Details
- Title: Subtitle
- The Effect of Receiving Treatment Within a Clinical Trial Setting on Survival and Quality of Care Perception in Advanced Stage Non-Small Cell Lung Cancer
- Creators
- Taher Abu-Hejleh - Department of Internal Medicine, Division of Hematology, Oncology, Blood & Marrow Transplantation, University of Iowa Hospitals and Clinics ‡Department of Internal Medicine and Program in Bioethics and Humanities, University of Iowa Hospitals and Clinics †University of Iowa Hospitals and Clinics §Department of Biostatistics, University of Iowa, Iowa City, IAElizabeth A ChrischillesThorvardur R HalfdanarsonChristian SimonJane F PendergastDingfeng JiangCarmen J SmithAaron T PorterKnute D CarterRobert B WallaceCancer Care Outcomes Research and Surveillance Consortium (CanCORS)
- Resource Type
- Journal article
- Publication Details
- American journal of clinical oncology, Vol.39(2), pp.126-131
- DOI
- 10.1097/COC.0000000000000029
- PMID
- 24632817
- PMCID
- PMC4411190
- NLM abbreviation
- Am J Clin Oncol
- ISSN
- 0277-3732
- eISSN
- 1537-453X
- Publisher
- United States
- Grant note
- U01 CA093344 / NCI NIH HHS U01 CA093326 / NCI NIH HHS U01 CA093324 / NCI NIH HHS U01 CA093339 / NCI NIH HHS U01 CA093332 / NCI NIH HHS U01 CA093348 / NCI NIH HHS U01 CA093329 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 04/2016
- Academic Unit
- Pharmacy; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Biostatistics; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983996189202771
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