Journal article
The Effect of Sedation on Long-Term Psychological Impairment After Extracorporeal Life Support
Journal of cardiothoracic and vascular anesthesia, Vol.34(3), pp.663-667
03/2020
DOI: 10.1053/j.jvca.2019.07.147
PMID: 31445835
Abstract
This retrospective study aimed to identify the association between long-term psychological impairment and total sedation received during venovenous extracorporeal life support (VV-ECLS) for acute respiratory failure (ARF).
This observational retrospective study compared characteristics between patients with and without long-term psychological morbidity at long-term follow-up after VV-ECLS for ARF.
A single institutional experience in a quaternary referral academic medical center in the United States.
Patients who received VV-ECLS for ARF between January 1, 2015, and April 1, 2017, were identified for selection. Presence of psychiatric morbidity (anxiety and/or depression) was determined with the Hospital Anxiety and Depression Subscale battery at long-term follow-up.
No interventions were made during this retrospective observational study.
A total of 42 patients (21 male, 21 female, median age 49 [interquartile range {IQR} 36-57]) completed a telephone interview a median of 14.6 (IQR 7.7-21.1) months after ECLS decannulation. Cohorts were defined as possessing any psychiatric morbidity (anxiety and/or depression) as defined by the Hospital Anxiety and Depression Subscale battery (n = 22 [52%]) versus no psychiatric morbidity (n = 20 [48%]) at long-term follow-up. Patients who had clinically significant psychiatric morbidity received a median of 15.0 (IQR 11.0-17.0) days of continuous intravenous sedation compared with patients who had no psychiatric morbidity, who received a median of 10.0 (IQR 6.5-13.5) days of intravenous sedation; (p = 0.02).
This retrospective analysis identified a significant association between the presence of long-term post-VV-ECLS psychiatric symptoms and the total number of days of intravenous sedation.
Details
- Title: Subtitle
- The Effect of Sedation on Long-Term Psychological Impairment After Extracorporeal Life Support
- Creators
- Michael D. McDonald - University of Pennsylvania Health SystemMeghan Lane-Fall - University of Pennsylvania Health SystemTodd A. Miano - University of PennsylvaniaMadeline Henry - University of Pennsylvania Health SystemColby Gallagher - University of Pennsylvania Health SystemRachel Hadler - University of Pennsylvania Health SystemKrzysztof Laudanski - University of Pennsylvania Health SystemEmily J. Mackay - University of Pennsylvania Health SystemAsad A. Usman - University of Pennsylvania Health SystemJacob Gutsche - University of Pennsylvania Health System
- Resource Type
- Journal article
- Publication Details
- Journal of cardiothoracic and vascular anesthesia, Vol.34(3), pp.663-667
- Publisher
- Elsevier Inc
- DOI
- 10.1053/j.jvca.2019.07.147
- PMID
- 31445835
- ISSN
- 1053-0770
- eISSN
- 1532-8422
- Language
- English
- Date published
- 03/2020
- Academic Unit
- Anesthesia
- Record Identifier
- 9984296145202771
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