Journal article
The Effect of Somatostatin on Coagulation and Platelet Function in Man
The New England journal of medicine, Vol.293(10), pp.480-483
09/04/1975
DOI: 10.1056/NEJM197509042931005
PMID: 1152862
Abstract
Preliminary evidence has suggested that somatostatin might interfere with platelet function in the baboon. Because this agent is currently being administered experimentally to human beings, we studied its effect on coagulation and platelet function in man. In five subjects, a four-hour infusion of somatostatin (500 μg per hour) had no definite effect on platelet count, leukocyte count, hematocrit, platelet adhesiveness and aggregation, bleeding time, partial thromboplastin time, prothrombin time, and fibrinogen levels. A similar infusion for 18 hours in three subjects was likewise without effect.
These studies indicate that somatostatin does not affect coagulation and platelet function in man and that its prolonged administration lacks ostensible toxicity. (N Engl J Med 293:480–483,1975)
SOMATOSTATIN is a hypothalamic peptide that inhibits the release of human growth hormone,
1
thyrotropin,
2
and, under certain conditions, prolactin and adrenocorticotropin
3
from the pituitary. In addition, it is a potent inhibitor of human pancreatic glucagon
4
5
6
and insulin
7
,
8
secretion. The ability of somatostatin to suppress glucagon secretion and thus to diminish both fasting and postprandial hyperglycemia in patients with diabetes mellitus
4
suggests that it may be of use as an adjunct to insulin in the treatment of this condition. The present studies were undertaken to assess the effect of somatostatin on human coagulation and platelet function because preliminary studies in baboons . . .
Details
- Title: Subtitle
- The Effect of Somatostatin on Coagulation and Platelet Function in Man
- Creators
- C. Harold MielkeJohn E GerichMara LorenziEva TsalikianRobert RodvienPeter H Forsham
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.293(10), pp.480-483
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJM197509042931005
- PMID
- 1152862
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 09/04/1975
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093372202771
Metrics
32 Record Views