Journal article
The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study
Journal of rheumatology, Vol.44(4), pp.493-498
04/2017
DOI: 10.3899/jrheum.160853
PMCID: PMC5468496
PMID: 28250143
Abstract
Whether widespread pain (WSP) affects the risk of developing knee pain or knee osteoarthritis (OA) is unknown and could enhance understanding of pain mechanisms in OA.
Subjects from the Multicenter OA (MOST) study, a US National Institutes of Health-funded prospective cohort of older adults with or at risk of knee OA, were characterized regarding WSP, defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, excluding knee pain at 60 months (baseline). Followup occurred 2 years later. We assessed the relation of WSP to odds of knee pain worsening (≥ 2-point increase in the Western Ontario and McMaster Universities Arthritis Index pain subscale) using logistic regression, and to odds of incident radiographic knee OA (ROA; Kellgren-Lawrence arthritis scale ≥ grade 2 of either knee among those free of ROA at baseline) and incident consistent frequent knee pain (CFKP; knee pain on most days during the past month among participants free of knee pain at baseline) in 1 or both knees using multinomial regression adjusting for potential confounders.
There were 1752 participants available for analysis [mean age (SD) 67.0 yrs (7.7), body mass index 30.5 kg/m
(5.9), 59% women]. Baseline presence of WSP was not associated with worsened knee pain (adjusted OR 1.15, 95% CI 0.89-1.48, p = 0.30), ROA (adjusted OR 0.86, 95% CI 0.46-1.63, p = 0.65), or incident CFKP (adjusted OR 1.69, 95% CI 0.96-2.96, p = 0.07).
WSP was not significantly associated with worsening knee pain, incident ROA, or CFKP. Development of knee pain and ROA does not appear to be influenced by underlying WSP.
Details
- Title: Subtitle
- The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study
- Creators
- Lisa C Carlesso - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine. lisa.carlesso@umontreal.caJingbo Niu - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of MedicineNeil A Segal - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of MedicineLaura A Frey-Law - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of MedicineCora E Lewis - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of MedicineMichael C Nevitt - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of MedicineTuhina Neogi - L.C. Carlesso, BSc PT, MSc PT, PhD, Assistant Professor, School of Rehabilitation, Faculty of Medicine, Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute; J. Niu, DSc, Boston University School of Medicine; N.A. Segal, MD, MS, Department of Rehabilitation Medicine, University of Kansas Medical Center; L.A. Frey-Law, MPT, MS, PhD, Associate Professor, Department of Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa; C.E. Lewis, MD, MSPH, Division of Preventive Medicine, University of Alabama at Birmingham, School of Medicine; M.C. Nevitt, PhD, Adjunct Professor, Department of Epidemiology and Biostatistics, University of California; T. Neogi, MD, PhD, Associate Professor of Medicine, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.44(4), pp.493-498
- DOI
- 10.3899/jrheum.160853
- PMID
- 28250143
- PMCID
- PMC5468496
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Publisher
- Canada
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS Canadian Institutes of Health Research K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Epidemiology; Nursing; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047863502771
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