The Effects of 3,3′,4,4′-tetrabromobiphenyl on Rats Fed Diets Containing a Constant Level of Copper and Varying Levels of Molybdenum

Kadhim N Salman; Mary A Stuart; Jack Schmidt; T Borges; Craig J McClain; Farrel R Robinson; Miao Li; Larry W Robertson

doi:10.1007/s11356-013-1638-5

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The Effects of 3,3′,4,4′-tetrabromobiphenyl on Rats Fed Diets Containing a Constant Level of Copper and Varying Levels of Molybdenum

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The Effects of 3,3′,4,4′-tetrabromobiphenyl on Rats Fed Diets Containing a Constant Level of Copper and Varying Levels of Molybdenum

Kadhim N Salman, Mary A Stuart, Jack Schmidt, T Borges, Craig J McClain, Farrel R Robinson, Miao Li and Larry W Robertson

Environmental science and pollution research international, Vol.21(10), pp.6400-6409

05/2014

DOI: 10.1007/s11356-013-1638-5

PMCID: PMC3732555

PMID: 23532536

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Abstract

Copper (Cu) metabolism is altered in rats fed diets high in molybdenum (Mo) and low in Cu. This 10-week study was carried out to examine the effects of supplemental Mo (7.5–240 μg/g diet) on male Sprague Dawley rats fed diets adequate in Cu (5 μg/g diet); and to determine the susceptibility of Mo-treated animals to the environmental pollutant 3,3′,4,4′-tetrabromobiphenyl (TBB). After seven weeks of dietary treatment, half the rats in each group received a single IP injection of TBB (150 μM/Kg bw), while the other half received the corn oil vehicle. Rats sacrificed at 10 weeks showed no effects of Mo on growth, feed efficiency, or selected organ or tissue weights. Dose-dependent effects on plasma Mo (0 – 5.1 μg/mL), Cu (0.95 – 0.20 μg/mL) and bone Cu (3.4 – 10 μg/g), in control through the high-dose were found. Cu sequestration in bone of Mo-treated rats is a new finding. TBB treatment resulted in dramatic weight loss and loss of absolute organ mass. Relative organ weights were increased, except for the thymus. TBB altered amino acid concentrations of certain amino acids. Compared to control rats, this polybrominated biphenyl congener significantly decreased plasma Cu and ceruloplasmin at higher concentrations of dietary Mo, and promoted the process of plasma Cu decrease by Mo, suggesting a combined effect.

Rats

PCBs

Diet

Copper

Molybdenum

PBBs

ISRP Project 1 2015-2020

Details

Title: Subtitle: The Effects of 3,3′,4,4′-tetrabromobiphenyl on Rats Fed Diets Containing a Constant Level of Copper and Varying Levels of Molybdenum
Creators: Kadhim N Salman - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Mary A Stuart - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Jack Schmidt - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
T Borges - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Craig J McClain - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Farrel R Robinson - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Miao Li - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Larry W Robertson - Department of Medicine, Robley Rex Louisville VAMC, Louisville, Kentucky 40206
Resource Type: Journal article
Publication Details: Environmental science and pollution research international, Vol.21(10), pp.6400-6409
DOI: 10.1007/s11356-013-1638-5
PMID: 23532536
PMCID: PMC3732555
NLM abbreviation: Environ Sci Pollut Res Int
ISSN: 0944-1344
eISSN: 1614-7499
Language: English
Date published: 05/2014
Academic Unit: Occupational and Environmental Health; Iowa Superfund Research Program
Record Identifier: 9984002373302771

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