Journal article
The Effects of Chronic Fluoxetine Treatment on Chronic Mild Stress-Induced Cardiovascular Changes and Anhedonia
Biological psychiatry (1969), Vol.59(4), pp.309-316
2006
DOI: 10.1016/j.biopsych.2005.07.010
PMID: 16154542
Abstract
Depression has a complex bidirectional association with heart disease. Previously we have shown notable cardiovascular changes in the chronic mild stress (CMS) rodent model of depression. Here we investigated the effects of a serotonin-specific reuptake inhibitor on a behavioral index of depression (anhedonia) and cardiac function in rats exposed to CMS.
Male Sprague-Dawley rats were exposed to either 4 weeks of control conditions or CMS, consisting of unpredictable periods of mild stressors, while being treated concurrently with 4 weeks of daily fluoxetine (10 mg/kg, sc) or vehicle.
Chronic fluoxetine treatment prevented anhedonia in rats exposed to CMS, versus the CMS group treated with vehicle. However, treatment with fluoxetine in the CMS group only partially prevented specific cardiovascular changes associated with CMS, including elevated resting heart rate (HR), exaggerated pressor and HR responses to air jet stress, reduced cardiac output and stroke volume, and HR exaggerated responses to β-adrenergic receptor blockade.
These findings provide evidence that 4 weeks of fluoxetine treatment can prevent behavioral responses and can partially prevent cardiovascular changes associated with CMS, providing insight into the role of serotonin in the link between depression and cardiovascular dysfunction.
Details
- Title: Subtitle
- The Effects of Chronic Fluoxetine Treatment on Chronic Mild Stress-Induced Cardiovascular Changes and Anhedonia
- Creators
- Angela J Grippo - Department of Psychology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IowaTerry G Beltz - Department of Psychology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IowaRobert M Weiss - Internal Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IowaAlan Kim Johnson - Department of Psychology, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.59(4), pp.309-316
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.biopsych.2005.07.010
- PMID
- 16154542
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 2006
- Academic Unit
- Psychological and Brain Sciences; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984094722602771
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