Journal article
The Effects of Ketamine Vary Among Inbred Mouse Strains and Mimic Schizophrenia for the P80, but not P20 or N40 Auditory ERP Components
Neurochemical research, Vol.29(6), pp.1179-1188
06/2004
DOI: 10.1023/B:NERE.0000023605.68408.fb
PMID: 15176475
Abstract
N-methyl-D-aspartate (NMDA) antagonists produce behavioral and electrophysiological effects similar to schizophrenia. The mouse P20, N40, and P80 event related potential (ERP) components were analyzed for genetic variance among inbred strains and ketamine-induced differences to model abnormalities in the P50, N100, and P200 in schizophrenia. Ketamine increased P20/N40 amplitude and decreased P80 amplitude. Therefore, the effects of ketamine in mice are inconsistent with alterations in the corresponding P50 and N100 in schizophrenia, suggesting that NMDA receptor dysfunction may not underlie abnormalities of these components in schizophrenia. However, the effects of ketamine on the mouse P80 were consistent with P200 ERP changes in schizophrenia and support the hypothesis that NMDA dysfunction may contribute to some neuronal abnormalities in schizophrenia. The current study lays the groundwork for defining the role of NMDA-mediated transmission for specific aspects of neuronal processing that vary with genetic background. Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems.
Details
- Title: Subtitle
- The Effects of Ketamine Vary Among Inbred Mouse Strains and Mimic Schizophrenia for the P80, but not P20 or N40 Auditory ERP Components
- Creators
- Patrick M Connolly - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaChristina Maxwell - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaYuling Liang - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaJonathan Kahn - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaStephen Kanes - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaTed Abel - Department of Biology University of Pennsylvania Philadelphia PennsylvaniaRaquel Gur - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaBruce Turetsky - Division of Neuropsychiatry, Department of Psychiatry University of Pennsylvania Philadelphia PennsylvaniaSteven Siegel - Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Neurochemical research, Vol.29(6), pp.1179-1188
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1023/B:NERE.0000023605.68408.fb
- PMID
- 15176475
- ISSN
- 0364-3190
- eISSN
- 1573-6903
- Language
- English
- Date published
- 06/2004
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065836502771
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