The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

Dao-Fu Dai; Jou-Wei Lin; Jia-Horng Kao; Chih-Neng Hsu; Fu-Tien Chiang; Jiunn-Lee Lin; Yi-Hua Chou; Kwan-Lih Hsu; Chuen-Den Tseng; Yung-Zu Tseng; Juey-Jen Hwang

doi:10.1210/jc.2006-2428

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The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

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The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

Dao-Fu Dai, Jou-Wei Lin, Jia-Horng Kao, Chih-Neng Hsu, Fu-Tien Chiang, Jiunn-Lee Lin, Yi-Hua Chou, Kwan-Lih Hsu, Chuen-Den Tseng, Yung-Zu Tseng, …

The journal of clinical endocrinology and metabolism, Vol.92(7), pp.2532-2537

07/01/2007

DOI: 10.1210/jc.2006-2428

PMID: 17426096

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Abstract

Abstract Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0–5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0–7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

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Title: Subtitle: The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events
Creators: Dao-Fu Dai - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Jou-Wei Lin - Department of Cardiovascular Center of National Taiwan University Hospital, Yun-Lin Branch (J.-W.L., J.-J.H.), Dou-Liou City, Yun-Lin 640, Taiwan
Jia-Horng Kao - Department of Graduate Institute of Clinical Medicine (J.-H.K.), College of Medicine, National Taiwan University, Taipei 100, Taiwan, Gastroenterology Division (J.-H.K.), National Taiwan University Hospital, Taipei 100, Taiwan
Chih-Neng Hsu - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Fu-Tien Chiang - Department of Internal Medicine, and Department of Laboratory Medicine (F.-T.C.), National Taiwan University Hospital, Taipei 100, Taiwan, Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Jiunn-Lee Lin - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Yi-Hua Chou - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Kwan-Lih Hsu - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Chuen-Den Tseng - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Yung-Zu Tseng - Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Juey-Jen Hwang - Department of Cardiovascular Center of National Taiwan University Hospital, Yun-Lin Branch (J.-W.L., J.-J.H.), Dou-Liou City, Yun-Lin 640, Taiwan, Cardiovascular Division (D.-F.D., C.-N.H., F.-T.C., J.-L.L., Y.-H.C., K.-L.H., C.-D.T., Y.-Z.T., J.-J.H.), National Taiwan University Hospital, Taipei 100, Taiwan
Resource Type: Journal article
Publication Details: The journal of clinical endocrinology and metabolism, Vol.92(7), pp.2532-2537
DOI: 10.1210/jc.2006-2428
PMID: 17426096
NLM abbreviation: J Clin Endocrinol Metab
ISSN: 0021-972X
eISSN: 1945-7197
Language: English
Date published: 07/01/2007
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984046900502771

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