Journal article
The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
Chemical research in toxicology, Vol.34(9), pp.1948-1952
09/20/2021
DOI: 10.1021/acs.chemrestox.1c00226
PMCID: PMC8456429
PMID: 34491731
Appears in UI Libraries Support Open Access
Abstract
Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.
Details
- Title: Subtitle
- The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review
- Creators
- Amanda J Bullert - Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USAJonathan A Doorn - Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USAHanna E Stevens - Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USAHans-Joachim Lehmler - Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.34(9), pp.1948-1952
- DOI
- 10.1021/acs.chemrestox.1c00226
- PMID
- 34491731
- PMCID
- PMC8456429
- NLM abbreviation
- Chem Res Toxicol
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Publisher
- American Chemical Society
- Number of pages
- 5
- Grant note
- ES005605; ES013661; ES014901; ES027169 / National Institute of Environmental Health Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 09/20/2021
- Academic Unit
- Psychiatry; Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984230637202771
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