Journal article
The Effects of Post-Diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analyses
Cancer epidemiology, biomarkers & prevention, Vol.34(8), pp.1252-1263
08/01/2025
DOI: 10.1158/1055-9965.EPI-24-1798
PMCID: PMC12314521
PMID: 40387563
Abstract
We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence and mortality to support individualized breast cancer survivorship care plans in clinical settings. Seven databases were searched to identify observational studies that examined the effects of exercise on recurrence, breast cancer-specific mortality (BCSM), and all-cause mortality (ACM) among female breast cancer survivors. Fully adjusted hazard ratios, and 95% confidence intervals were extracted for comparisons reported in relation to no/minimal exercise (reference). Dose-response relationships between exercise and events were examined using restricted cubic splines. Under half (44.3%, n=50,689) met aerobic exercise guidelines for health (≥~2.5hrs/wk). Meeting guidelines was associated with a ~50% reduction in the hazard ratio for ACM, with further reductions up to ~4.5hrs/wk. A ~25% reduction in the hazard ratio for ACM was associated with ~1hr/wk. The 5-year (unadjusted) ACM rates were 11% for no/minimal exercise, 4% for insufficient exercise, and 3% for meeting exercise guidelines (n=5 studies). There were limited data for subgroups. Similar patterns were observed for recurrence and BCSM. Exercise may lower the risk of recurrence and mortality among breast cancer survivors. Though meeting guidelines for health offers the greatest benefits, exercise below guidelines is also beneficial.
Details
- Title: Subtitle
- The Effects of Post-Diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analyses
- Creators
- Oliver Wa Wilson - National Institute on Minority Health and Health DisparitiesCharles E Matthews - National Cancer InstituteKaitlyn M Wojcik - National Institute on Minority Health and Health DisparitiesYelena N Tarasenko - Georgia Southern UniversityGisela Butera - National Institutes of HealthJessica Gorzelitz - University of IowaClyde Schechter - Albert Einstein College of MedicineJennifer Y Sheng - Johns Hopkins MedicineJinani Jayasekera - National Institute on Minority Health and Health Disparities
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.34(8), pp.1252-1263
- DOI
- 10.1158/1055-9965.EPI-24-1798
- PMID
- 40387563
- PMCID
- PMC12314521
- NLM abbreviation
- Cancer Epidemiol Biomarkers Prev
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Publisher
- AMER ASSOC CANCER RESEARCH
- Grant note
- National Institute on Minority Health and Health Disparities (NIMHD): ZIA MD000022 Division of Intramural Research at the National Institute on Minority Health and Health Disparities of the NIH: 1 ZIJ MD000009-07 National Institute on Minority Health and Disparities Coleman Research Innovation AwardDivision of Cancer Epidemiology and Genetics at the NCI: 3R01CA254628-03S1 NCI Diversity supplement
The authors would like to acknowledge Dalya Kamil, Kaylee Sanger, and Lauren Cooper who assisted with screening. J. Jayasekera, O.W.A. Wilson, K.M. Wojcik, and C. Schechter were supported by the Division of Intramural Research at the National Institute on Minority Health and Health Disparities of the NIH (ZIA MD000022). O.W.A. Wilson was also supported by the National Institute on Minority Health and Disparities Coleman Research Innovation Award (1 ZIJ MD000009-07). C.E. Matthews was supported by the Division of Cancer Epidemiology and Genetics at the NCI. J. Gorzelitz is supported by an NCI Diversity supplement (3R01CA254628-03S1).
- Language
- English
- Electronic publication date
- 05/19/2025
- Date published
- 08/01/2025
- Academic Unit
- Obstetrics and Gynecology; Health, Sport, and Human Physiology
- Record Identifier
- 9984824283602771
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